Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/12654
DC Field | Value | Language |
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dc.contributor.author | Sena, C. M. | - |
dc.contributor.author | Nunes, E. | - |
dc.contributor.author | Louro, T. | - |
dc.contributor.author | Proença, T. | - |
dc.contributor.author | Fernandes, R. | - |
dc.contributor.author | Boarder, M. R. | - |
dc.contributor.author | Seiça, R. M. | - |
dc.date.accessioned | 2010-03-03T09:57:48Z | - |
dc.date.available | 2010-03-03T09:57:48Z | - |
dc.date.issued | 2008-03 | - |
dc.identifier.citation | British Journal of Pharmacology. 153:5 (2008) 894-906 | en_US |
dc.identifier.issn | 0007-1188 | - |
dc.identifier.uri | https://hdl.handle.net/10316/12654 | - |
dc.description.abstract | Background and purpose: This study was conducted to investigate the effects of α-lipoic acid (α-LA) on endothelial function in diabetic and high-fat fed animal models and elucidate the potential mechanism underlying the benefits of α-LA. Experimental approach: Plasma metabolites reflecting glucose and lipid metabolism, endothelial function, urinary albumin excretion (UAE), plasma and aortic malondialdehyde (MDA) and urinary 8-hydroxydeoxyguanosine (8-OHdG) were assessed in non-diabetic controls (Wistar rats), untreated Goto-Kakizaki (GK) diabetic and high-fat fed GK rats (fed with atherogenic diet only, treated with α-LA and treated with vehicle, for 3 months). Vascular eNOS, nitrotyrosine, carbonyl groups and superoxide anion were also assessed in the different groups. Key results: α-LA and soybean oil significantly reduced both total and non-HDL serum cholesterol and triglycerides induced by atherogenic diet. MDA, carbonyl groups, vascular superoxide and 8-OHdG levels were higher in GK and high-fat fed GK groups and fully reversed with α-LA treatment. High-fat fed GK diabetic rats showed significantly reduced endothelial function and increased UAE, effects ameliorated with α-LA. This endothelial dysfunction was associated with decreased NO production, decreased expression of eNOS and increased vascular superoxide production and nitrotyrosine expression. Conclusions and implications: α-LA restores endothelial function and significantly improves systemic and local oxidative stress in high-fat fed GK diabetic rats. Improved endothelial function due to α-LA was at least partially attributed to recoupling of eNOS and increased NO bioavailability and represents a pharmacological approach to prevent major complications associated with type 2 diabetes | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.rights | openAccess | en_US |
dc.subject | Type 2 diabetes | en_US |
dc.subject | High-fat diet | en_US |
dc.subject | α-lipoic acid | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Endothelial function | en_US |
dc.subject | eNOS | en_US |
dc.subject | Nitric oxide | en_US |
dc.subject | Atherosclerosis | en_US |
dc.title | Effects of alpha-lipoic acid on endothelial function in aged diabetic and high-fat fed rats | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1038/sj.bjp.0707474 | - |
uc.controloAutoridade | Sim | - |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-0889-2977 | - |
crisitem.author.orcid | 0000-0002-8378-0895 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Effects of α-lipoic acid on endothelial function.pdf | 423.28 kB | Adobe PDF | View/Open |
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