Title: Alterations of retinal capillary blood flow in preclinical retinopathy in subjects with type 2 diabetes
Authors: Ludovico, José 
Bernardes, Rui 
Pires, Isabel 
Figueira, João 
Lobo, Conceição 
Cunha-Vaz, José 
Issue Date: Mar-2003
Publisher: Springer
Citation: Graefe's Archive for Clinical and Experimental Ophthalmology. 241:3 (2003) 181-186
Abstract: Background: To identify alterations of retinal capillary blood flow in the papillomacular area in preclinical diabetic retinopathy using the Heidelberg scanning laser Doppler flowmeter. Methods: Ten eyes from ten patients with type 2 diabetes and no lesions visible on fundus photography (level 10 of Wisconsin grading) and ten eyes from ten healthy subjects of similar age range were examined with the HRF. Intravisit reproducibility of retinal capillary blood flow measurements was assessed in normal subjects and in type 2 diabetic patients, comparing different measurement areas and different analysis procedures: (a) 10×10 pixel box with original software, (b) 10×10 pixel box with SLDF software, and (c) whole-scan analysis with SLDF software (automatic full-field perfusion image analysis). Results: Intravisit reproducibility for the wholescan analysis in the papillomacular area was 3.52%, 4.81% and 4.60% for volume (VOL), flow (FLW) and velocity (VEL) respectively. Using this method, mean and SD values for retinal capillary blood-flow are 13.25±2.87, 214.58±55.30 and 0.74±0.17, for VOL, FLW and VEL for healthy eyes, comparing with 19.85±6.22, 360.87±158.70 and 1.20±0.48 in eyes with preclinical diabetic retinopathy (P<0.010, P<0.019 and P<0.015 respectively). Conclusions: The HRF shows acceptable reproducibility when using whole-scan analysis in the papillomacular area. Retinal capillary blood VOL, FLW and VEL were particularly increased in five of the ten diabetic eyes examined, with values over the mean + 2SD of the control population, suggesting that eyes showing increased retinal capillary blood flow may indicate risk of progression.
URI: http://hdl.handle.net/10316/11823
ISSN: 0721-832X
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

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