Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/11789
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Rosa, Susana C. | - |
dc.contributor.author | Gonçalves, Juliana | - |
dc.contributor.author | Judas, Fernando | - |
dc.contributor.author | Mobasheri, Ali | - |
dc.contributor.author | Lopes, Celeste | - |
dc.contributor.author | Mendes, Alexandrina Ferreira | - |
dc.date.accessioned | 2009-10-20T15:27:04Z | - |
dc.date.available | 2009-10-20T15:27:04Z | - |
dc.date.issued | 2009-06-02 | - |
dc.identifier.citation | ROSA, Susana C. et al. - Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage. Arthritis Research & Therapy Vol 11 No 3.R80 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/11789 | - |
dc.description.abstract | Introduction Disorders that affect glucose metabolism, namely diabetes mellitus (DM), may favor the development and/or progression of osteoarthritis (OA). Thus far, little is known regarding the ability of chondrocytes to adjust to variations in the extracellular glucose concentration, resulting from hypoglycemia and hyperglycemia episodes, and so, to avoid deleterious effects resulting from deprivation or intracellular accumulation of glucose. The aim of this study was to compare the ability of normal and OA chondrocytes to regulate their glucose transport capacity in conditions of insufficient or excessive extracellular glucose and to identify the mechanisms involved and eventual deleterious consequences, namely the production of reactive oxygen species (ROS). | en_US |
dc.description.sponsorship | 1Center for Neurosciences and Cell Biology, and Faculty of Pharmacy, University of Coimbra, 3004-517 Coimbra, Portugal 2Orthopaedics Department, University Hospital of Coimbra, Avenida Bissaya Barreto, Bloco de Celas, 3000-075 Coimbra, Portugal 3Division of Veterinary Medicine, School of Veterinary Science and Medicine, Sutton Bonington Campus, University of Nottingham, Sutton Bonington LE12 5RD, UK | en_US |
dc.language.iso | eng | en_US |
dc.publisher | BioMedCentral | en_US |
dc.rights | openAccess | en_US |
dc.subject | diabetes mellitus | en_US |
dc.subject | osteoartrite | en_US |
dc.title | Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1186/ar2713 | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0001-5511-7132 | - |
Aparece nas coleções: | FFUC- Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
AR&T_2009.pdf | 1.45 MB | Adobe PDF | Ver/Abrir |
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