Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/116195
DC Field | Value | Language |
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dc.contributor.author | Magalhães, Mariana | - |
dc.contributor.author | Domínguez-Martín, Eva María | - |
dc.contributor.author | Jorge, Joana | - |
dc.contributor.author | Gonçalves, Ana Cristina | - |
dc.contributor.author | Massenzio, Francesca | - |
dc.contributor.author | Spigarelli, Renato | - |
dc.contributor.author | Ribeiro-Rodrigues, Teresa | - |
dc.contributor.author | Catarino, Steve | - |
dc.contributor.author | Girão, Henrique | - |
dc.contributor.author | Monti, Barbara | - |
dc.contributor.author | Spisni, Enzo | - |
dc.contributor.author | Ferreira, Lino | - |
dc.contributor.author | Oliveira, Paulo J. | - |
dc.contributor.author | Efferth, Thomas | - |
dc.contributor.author | Rijo, Patrícia | - |
dc.contributor.author | Cabral, Célia Margarida dos Santos | - |
dc.date.accessioned | 2024-09-03T15:18:06Z | - |
dc.date.available | 2024-09-03T15:18:06Z | - |
dc.date.issued | 2024-08-14 | - |
dc.identifier.citation | Mariana Magalhães, Eva María Domínguez-Martín, Joana Jorge, Ana Cristina Gonçalves, Francesca Massenzio, Renato Spigarelli, Teresa Ribeiro-Rodrigues, Steve Catarino, Henrique Girão, Barbara Monti, Enzo Spisni, Lino Ferreira, Paulo J. Oliveira, Thomas Efferth, Patrícia Rijo, Célia Cabral, Unveiling the antitumor mechanism of 7α-acetoxy-6β-hydroxyroyleanone from Plectranthus hadiensis in glioblastoma, Journal of Ethnopharmacology, Volume 335, 2024, 118689, ISSN 0378-8741, https://doi.org/10.1016/j.jep.2024.118689. | pt |
dc.identifier.issn | 03788741 | - |
dc.identifier.uri | https://hdl.handle.net/10316/116195 | - |
dc.description.abstract | Glioblastoma (GB) is the most aggressive and prevalent glioma within the central nervous system. Despite considerable efforts, GB continues to exhibit a dismal 5-year survival rate (∼6%). This is largely attributed to unfavorable prognosis and lack of viable treatment options. Therefore, novel therapies centered around plant-derived compounds emerge as a compelling avenue to enhance patient survival and well-being. The South African species, Plectranthus hadiensis Schweinf. (P. hadiensis), a member of the Lamiaceae family, has a history of use in traditional medicine for treating a range of diseases, including respiratory, digestive, and liver disorders. This species exhibits diverse biological activities, such as anti-inflammatory and antitumoral properties, likely attributed to its rich composition of naturally occurring diterpenes, like the abietane diterpene, 7α-acetoxy-6β-hydroxyroyleanone (Roy). Roy has demonstrated promising antitumor effects in various cancer cell lines, making it a compelling candidate for further investigation into its mechanisms against GB. | pt |
dc.language.iso | eng | pt |
dc.publisher | Elsevier - Journal of Ethnopharmacology | pt |
dc.relation | SFRH/BD/146441/2019 | pt |
dc.relation | UIDB/04539/2020 | pt |
dc.relation | info:eu-repo/grantAgreement/UIDP/04539/2020 | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA/P/0058/2020/PT | pt |
dc.relation | SFRH/BD/145531/2019 | pt |
dc.rights | openAccess | pt |
dc.subject | Abietane diterpenes | pt |
dc.subject | Antitumor activity | pt |
dc.subject | Glioblastoma | pt |
dc.subject | Plectranthus hadiensis schweinf. | pt |
dc.subject | Royleanone | pt |
dc.title | Unveiling the antitumor mechanism of 7α-acetoxy-6β-hydroxyroyleanone from Plectranthus hadiensis in glioblastoma | pt |
dc.type | article | pt |
degois.publication.firstPage | 118689 | pt |
degois.publication.title | Journal of Ethnopharmacology | pt |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/abs/pii/S0378874124009887?via%3Dihub | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1016/j.jep.2024.118689 | - |
degois.publication.volume | 335 | pt |
dc.date.embargo | 2024-08-14 | * |
dc.identifier.pmid | 39128799 | - |
uc.date.periodoEmbargo | 0 | pt |
dc.identifier.eissn | 1872-7573 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.fulltext | Com Texto completo | - |
item.cerifentitytype | Publications | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology - CIBB | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology - Associate Laboratory | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.orcid | 0000-0002-1874-1611 | - |
crisitem.author.orcid | 0000-0003-1470-4802 | - |
crisitem.author.orcid | 0000-0001-9644-6960 | - |
crisitem.author.orcid | 0000-0002-5786-8447 | - |
crisitem.author.orcid | 0000-0001-8985-9302 | - |
crisitem.author.orcid | 0000-0002-5201-9948 | - |
crisitem.author.orcid | 0000-0003-4562-6683 | - |
Appears in Collections: | I&D CIBB - Artigos em Revistas Internacionais |
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1-s2.0-S0378874124009887-main.pdf | 9.03 MB | Adobe PDF | View/Open |
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