Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/116157
DC Field | Value | Language |
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dc.contributor.author | Sousa, Diana Isabel Teixeira de | - |
dc.contributor.author | Magalhães, Carina C. | - |
dc.contributor.author | Matafome, Paulo | - |
dc.contributor.author | Pereira, Susana P. | - |
dc.date.accessioned | 2024-08-28T11:55:22Z | - |
dc.date.available | 2024-08-28T11:55:22Z | - |
dc.date.issued | 2024-08-28 | - |
dc.identifier.issn | 0144-8463 | - |
dc.identifier.issn | 1573-4935 | - |
dc.identifier.uri | https://hdl.handle.net/10316/116157 | - |
dc.description.abstract | Obesity during pregnancy has been escalating, becoming a huge problem that poses consequences not only for the health of the offspring but also for the maternal well-being. Women's adipose and hepatic tissue metabolism undergoes significant changes during the gestational period. During pregnancy, obesity is a primary instigator of steatosis, increasing the risk of non-alcholic fatty liver disease (NAFLD), now recognized under the updated nomenclature metabolic dysfunction-associated steatotic liver disease (MASLD). Pregnant women with obesity present higher levels of free fatty acids and glucose, reduction in insulin sensitivity, and adipose tissue endocrine dysregulation. Furthermore, obesity-induced modifications in clock genes and lipid-associated gene expression within adipose tissue disrupt crucial metabolic adaptations, potentially culminating in adipose tissue dysfunction. Thus, the liver experiences increased exposure to free fatty acids through the portal vein. Higher uptake of free fatty acids into the liver disrupts hepatic lipid oxidation while enhances lipogenesis, thereby predisposing to ectopic fat deposition within the liver. This review focuses on the obesity-induced changes during pregnancy in both liver and adipose tissue metabolism, elucidating how the metabolic crosstalk between these two organs can be dysregulated in pregnant women living with obesity. | pt |
dc.description.sponsorship | The authors D.S., C.M., and S.P.P. were funded by the ERDF funds through the Operational Programme for CompetitivenessCOMPETE 2020 and national funds by Foundation for Science and Technology under the FCT-Post-doctoral Fellowship [grant number SPP, SFRH/BPD/116061/2016]; project grant [grant numbers HORIZON-HLTH-2022-STAYHLTH-101080329, PTDC/DTP-DES/1082/2014 (POCI-01-0145-FEDER-016657)]; strategic projects [grant numbers UIDB/04539/2020, UIDP/04539/2020, LA/P/0058/2020, UIDB/00617/2020: doi:10.54499/UIDB/00617/2020 and UIDP/00617/2020: doi:10.54499/ UIDP/00617/2020]; PhD grant from the the European’s Union Horizon Europe project CHAngeing - Connected Hubs in Ageing: Healthy Living to Protect Cerebrovascular Function under the GA No 101087071 and a research grant from the from the European’s Union Horizon Europe project PAS GRAS under the GA [grant number 101080329]. This work was supported by “CHAngeing - Connected Hubs in Ageing: Healthy Living to Protect Cerebrovascular Function” funded by the European Union’s Horizon Europe program (Excellence Hubs - HORIZON-WIDERA-2022-ACCESS-04-01) under grant agreement No. 101087071 and by the European’s Union Horizon Europe project PAS GRAS under the GA No 101080329. | pt |
dc.language.iso | eng | pt |
dc.relation | info:eu-repo/grantAgreement/HE/101087071/CHAngeing | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB/04539/2020 | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP/04539/2020 | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA/P/0058/2020/PT | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB/00617/2020 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Gestational obesity | pt |
dc.subject | Intrahepatic lipid accumulation | pt |
dc.subject | Maternal metabolic health | pt |
dc.subject | Metabolic Dysfunction-Associated Steatotic Liver Disease | pt |
dc.subject | Molecular bases of diseases | pt |
dc.subject | hepatic steatosis | pt |
dc.title | Adipose tissue-liver cross-talk: a route to hepatic dysfunction in pregnant women with obesity | pt |
dc.type | article | pt |
degois.publication.issue | 8 | pt |
degois.publication.title | Bioscience Reports | pt |
dc.relation.publisherversion | https://portlandpress.com/bioscirep/article/44/8/BSR20231679/234755/Adipose-tissue-liver-cross-talk-a-route-to-hepatic | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1042/BSR20231679 | - |
degois.publication.volume | 44 | pt |
dc.date.embargo | 2024-08-28 | * |
dc.identifier.pmid | 39083072 | - |
uc.date.periodoEmbargo | 0 | pt |
dc.identifier.eissn | 1573-4935 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.fulltext | Com Texto completo | - |
item.cerifentitytype | Publications | - |
crisitem.project.grantno | Connected Hubs in Ageing: Healthy Living to Protect Cerebrovascular Function | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology - CIBB | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology - Associate Laboratory | - |
crisitem.project.grantno | Research Center in Physical Activity , Health and Leisure - CIAFEL | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-3422-290X | - |
crisitem.author.orcid | 0000-0002-1168-2444 | - |
Appears in Collections: | I&D ICBR - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Adipose tissue-liver cross-talk a route to hepatic dysfunction in pregnant women with obesity.pdf | 1.8 MB | Adobe PDF | View/Open |
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