Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/114906
DC Field | Value | Language |
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dc.contributor.author | de Bem Alves, Ana Cristina | - |
dc.contributor.author | Speck, Ana Elisa | - |
dc.contributor.author | Farias, Hémelin Resende | - |
dc.contributor.author | Martins, Leo Meira | - |
dc.contributor.author | Dos Santos, Naiara Souza | - |
dc.contributor.author | Pannata, Gabriela | - |
dc.contributor.author | Tavares, Ana Paula Gomes | - |
dc.contributor.author | de Oliveira, Jade | - |
dc.contributor.author | Tomé, Ângelo R. | - |
dc.contributor.author | Cunha, Rodrigo A. | - |
dc.contributor.author | Aguiar, Aderbal S. | - |
dc.date.accessioned | 2024-04-17T09:54:11Z | - |
dc.date.available | 2024-04-17T09:54:11Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.issn | 1573-9538 | pt |
dc.identifier.issn | 1573-9546 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/114906 | - |
dc.description.abstract | Caffeine is one of the main ergogenic resources used in exercise and sports. Previously, we reported the ergogenic mechanism of caffeine through neuronal A2AR antagonism in the central nervous system [1]. We now demonstrate that the striatum rules the ergogenic effects of caffeine through neuroplasticity changes. Thirty-four Swiss (8-10 weeks, 47 ± 1.5 g) and twenty-four C57BL/6J (8-10 weeks, 23.9 ± 0.4 g) adult male mice were studied behaviorly and electrophysiologically using caffeine and energy metabolism was studied in SH-SY5Y cells. Systemic (15 mg/kg, i.p.) or striatal (bilateral, 15 μg) caffeine was psychostimulant in the open field (p < 0.05) and increased grip efficiency (p < 0.05). Caffeine also shifted long-term depression (LTD) to potentiation (LTP) in striatal slices and increased the mitochondrial mass (p < 0.05) and membrane potential (p < 0.05) in SH-SY5Y dopaminergic cells. Our results demonstrate the role of the striatum in the ergogenic effects of caffeine, with changes in neuroplasticity and mitochondrial metabolism. | pt |
dc.language.iso | eng | pt |
dc.publisher | Springer Nature | pt |
dc.relation | LCF/PR/HP17/52190001 | pt |
dc.relation | POCI-01- 0145-FEDER-03127 | pt |
dc.relation | CENTRO-01-0145-FEDER-000008 | pt |
dc.relation | info:eu-repo/grantAgreement/UIDB/04539/2020 | pt |
dc.relation | CENTRO-01-0246-FEDER-000010 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Caffeine | pt |
dc.subject | Dopamine | pt |
dc.subject | Grip strength | pt |
dc.subject | Mitochondria | pt |
dc.subject | Neuroplasticity | pt |
dc.subject | Striatum | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Mice | pt |
dc.subject.mesh | Animals | pt |
dc.subject.mesh | Caffeine | pt |
dc.subject.mesh | Mice, Inbred C57BL | pt |
dc.subject.mesh | Performance-Enhancing Substances | pt |
dc.subject.mesh | Neuroblastoma | pt |
dc.subject.mesh | Central Nervous System Stimulants | pt |
dc.title | The striatum drives the ergogenic effects of caffeine | pt |
dc.type | article | - |
degois.publication.firstPage | 673 | pt |
degois.publication.lastPage | 683 | pt |
degois.publication.issue | 4 | pt |
degois.publication.title | Purinergic Signalling | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1007/s11302-023-09922-5 | pt |
degois.publication.volume | 19 | pt |
dc.date.embargo | 2023-12-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology - CIBB | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0001-8671-989X | - |
crisitem.author.orcid | 0000-0003-2550-6422 | - |
crisitem.author.orcid | 0000-0002-6825-3333 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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The-striatum-drives-the-ergogenic-effects-of-caffeinePurinergic-Signalling.pdf | 2.8 MB | Adobe PDF | View/Open |
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