Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/114833
DC Field | Value | Language |
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dc.contributor.author | Sousa, Cátia | - |
dc.contributor.author | Neves, Bruno Miguel | - |
dc.contributor.author | Leitão, Alcino Jorge | - |
dc.contributor.author | Mendes, Alexandrina F. | - |
dc.date.accessioned | 2024-04-15T08:25:46Z | - |
dc.date.available | 2024-04-15T08:25:46Z | - |
dc.date.issued | 2023-01-11 | - |
dc.identifier.issn | 1999-4923 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/114833 | - |
dc.description.abstract | To explore the molecular mechanisms underlying the anti-inflammatory activity of (R)-(-)-carvone, we evaluated its ability to inhibit the signaling pathways involving the mitogen-activated protein kinases (MAPKs) and the transcription factor, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). (R)-(-)-carvone significantly decreased c-Jun N-terminal kinase (JNK) 1phosphorylation, but not that of the other MAPKs, induced by bacterial lipopolysaccharides (LPS) in the RAW 264.7 macrophage cell line. Although (R)-(-)-carvone significantly inhibited resynthesis of the inhibitor of NF-κB (IκB)-α induced by LPS, it did not interfere with the canonical NF-κB activation pathway, suggesting that it may interfere with its transcriptional activity. (R)-(-)-carvone also showed a tendency to decrease the levels of acetylated NF-κB/p65 in the nucleus, without affecting the activity and protein levels of Sirtuin-1, the major NF-κB/p65 deacetylating enzyme. Interestingly, the nuclear protein levels of the transcription factor, nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and the expression of its target,, heme oxygenase-1 (HO-1), an antioxidant enzyme, also showed a tendency to increase in the presence of (R)-(-)-carvone. Taken together, these results suggest that the ability of (R)-(-)-carvone to inhibit JNK1 and to activate Nrf2 can underlie its capacity to inhibit the transcriptional activity of NF-κB and the expression of its target genes. This study highlights the diversity of molecular mechanisms that can be involved in the anti-inflammatory activity of monoterpenes. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | POCI-01-0145-FEDER-028424 (CARTILFACTORY) | pt |
dc.relation | UIDB/04539/2020 | pt |
dc.relation | UIDP/04539/2020 | pt |
dc.relation | LA/P/0058/2020 | pt |
dc.relation | PhD fellowship SFRH/79600/2011 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | (R)-(-)-carvone | pt |
dc.subject | MAPKs | pt |
dc.subject | NF-κB | pt |
dc.subject | Nrf2 | pt |
dc.subject | aging | pt |
dc.subject | inflammation | pt |
dc.title | Molecular Mechanisms Underlying the Anti-Inflammatory Properties of (R)-(-)-Carvone: Potential Roles of JNK1, Nrf2 and NF-κB | pt |
dc.type | article | - |
degois.publication.firstPage | 249 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Pharmaceutics | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/pharmaceutics15010249 | pt |
degois.publication.volume | 15 | pt |
dc.date.embargo | 2023-01-11 | * |
uc.date.periodoEmbargo | 0 | pt |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0001-5511-7132 | - |
Appears in Collections: | I&D CIBB - Artigos em Revistas Internacionais FFUC- Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Molecular-Mechanisms-Underlying-the-AntiInflammatory-Properties-of-RCarvone-Potential-Roles-of-JNK1-Nrf2-and-NFBPharmaceutics.pdf | 3.71 MB | Adobe PDF | View/Open |
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