Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/114809
DC Field | Value | Language |
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dc.contributor.author | Silva, Jorge Miguel Alves | - |
dc.contributor.author | Gonçalves, Maria José | - |
dc.contributor.author | Silva, Ana | - |
dc.contributor.author | Cavaleiro, Carlos | - |
dc.contributor.author | Cruz, M. Teresa | - |
dc.contributor.author | Salgueiro, Lígia | - |
dc.date.accessioned | 2024-04-12T10:35:57Z | - |
dc.date.available | 2024-04-12T10:35:57Z | - |
dc.date.issued | 2023-01-15 | - |
dc.identifier.issn | 2079-6382 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/114809 | - |
dc.description.abstract | Fungal infections and the accompanying inflammatory responses are associated with great morbidity and mortality due to the frequent relapses triggered by an increased resistance to antifungal agents. Furthermore, this inflammatory state can be exacerbated during inflammaging and cellular senescence. Essential oils (EO) are receiving increasing interest in the field of drug discovery due to their lipophilic nature and complex composition, making them suitable candidates in the development of new antifungal drugs and modulators of numerous molecular targets. This work chemically characterized the EO from Santolina rosmarinifolia L., collected in Setúbal (Portugal), and assessed its antifungal potential by determining its minimum inhibitory (MIC) and minimum lethal (MLC) concentration in accordance with the Clinical Laboratory Standard Guidelines (CLSI) guidelines, as well as its effect on several Candida albicans virulence factors. The anti-inflammatory effect was unveiled using lipopolysaccharide (LPS)-stimulated macrophages by assessing several pro-inflammatory mediators. The wound healing and anti-senescence potential of the EO was also disclosed. The EO was mainly characterized by β-pinene (29.6%), borneol (16.9%), myrcene (15.4%) and limonene (5.7%). It showed a strong antifungal effect against yeasts and filamentous fungi (MIC = 0.07-0.29 mg/mL). Furthermore, it inhibited dimorphic transition (MIC/16), decreased biofilm formation with a preeminent effect after 24 h (MIC/2) and disrupted preformed biofilms in C. albicans. Additionally, the EO decreased nitric oxide (NO) release (IC50 = 0.52 mg/mL) and pro-IL-1β and inducible nitric oxide synthase (iNOS) expression in LPS-stimulated macrophages, promoted wound healing (91% vs. 81% closed wound) and reduced cellular senescence (53% vs. 73% β-galactosidase-positive cells). Overall, this study highlights the relevant pharmacological properties of S. rosmarinifolia, opening new avenues for its industrial exploitation. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | UIDB/04539/2020 | pt |
dc.relation | UIDP/04539/2020 | pt |
dc.relation | LA/P/0058/2020 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | anti-inflammatory | pt |
dc.subject | antifungal | pt |
dc.subject | Asteraceae | pt |
dc.subject | dimorphic transition | pt |
dc.subject | biofilm | pt |
dc.subject | senescence | pt |
dc.subject | wound healing | pt |
dc.title | Chemical Profile, Anti-Microbial and Anti-Inflammaging Activities of Santolina rosmarinifolia L. Essential Oil from Portugal | pt |
dc.type | article | - |
degois.publication.firstPage | 179 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Antibiotics | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/antibiotics12010179 | pt |
degois.publication.volume | 12 | pt |
dc.date.embargo | 2023-01-15 | * |
uc.date.periodoEmbargo | 0 | pt |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CIEPQPF – Chemical Process Engineering and Forest Products Research Centre | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0002-5270-3993 | - |
crisitem.author.orcid | 0000-0002-4041-0376 | - |
crisitem.author.orcid | 0000-0002-5937-1127 | - |
crisitem.author.orcid | 0000-0001-9846-6754 | - |
crisitem.author.orcid | 0000-0003-0948-821X | - |
Appears in Collections: | FCTUC Eng.Química - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais I&D CIEPQPF - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais FFUC- Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Chemical-Profile-AntiMicrobial-and-AntiInflammaging-Activities-of-Santolina-rosmarinifolia-L-Essential-Oil-from-PortugalAntibiotics.pdf | 4.06 MB | Adobe PDF | View/Open |
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