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Title: | Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria | Authors: | Diyaolu, Oluwatofunmilayo A. Preet, Gagan Fagbemi, Adeshola A. Annang, Frederick Pérez-Moreno, Guiomar Bosch-Navarrete, Cristina Adebisi, Olusoji O. Oluwabusola, Emmanuel T. Milne, Bruce F. Jaspars, Marcel Ebel, Rainer |
Keywords: | Aspergillus fumigatus; OSMAC; metabolomics; molecular docking; antitrypanosomal; antiplasmodial; in silico molecular docking | Issue Date: | 6-Jan-2023 | Publisher: | MDPI | Project: | Schlumberger Foundation Faculty for the Future Scholarship Program UIDB/04564/2020 UIDP/04564/2020 |
Serial title, monograph or event: | Antibiotics | Volume: | 12 | Issue: | 1 | Abstract: | In this study, we explored a fungal strain UIAU-3F identified as Aspergillus fumigatus isolated from soil samples collected from the River Oyun in Kwara State, Nigeria. In order to explore its chemical diversity, the fungal strain UIAU-3F was cultured in three different fermentation media, which resulted in different chemical profiles, evidenced by LC-ESI-MS-based metabolomics and multivariate analysis. The methanolic extract afforded two known compounds, fumitremorgin C (1) and pseurotin D (2). The in vitro antiparasitic assays of 1 against Trypanosoma cruzi and Plasmodium falciparum showed moderate activity with IC50 values of 9.6 µM and 2.3 µM, respectively, while 2 displayed IC50 values > 50 µM. Molecular docking analysis was performed on major protein targets to better understand the potential mechanism of the antitrypanosomal and antiplasmodial activities of the two known compounds. | URI: | https://hdl.handle.net/10316/114777 | ISSN: | 2079-6382 | DOI: | 10.3390/antibiotics12010109 | Rights: | openAccess |
Appears in Collections: | FCTUC Física - Artigos em Revistas Internacionais I&D CFis - Artigos em Revistas Internacionais |
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