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https://hdl.handle.net/10316/114176
Title: | Metformin in SARS-CoV-2 infection: A hidden path - from altered inflammation to reduced mortality. A review from the literature | Authors: | Pedrosa, Ana Realista Martins, Diana Cruz Rizzo, Manfredi Silva-Nunes, José |
Keywords: | Metformin; SARS-CoV-2; COVID-19; Diabetes; Mortality; Severity | Issue Date: | Feb-2023 | Publisher: | Elsevier | Serial title, monograph or event: | Journal of Diabetes and its Complications | Volume: | 37 | Issue: | 2 | Abstract: | SARS-CoV-2 infection has been a major threat to human health and a huge challenge to Medicine. In only two years, COVID-19 affected >350 million people, causing >5.6 million deaths. Chronic inflammatory states, such as diabetes or obesity, are known risk factors for COVID-19 poorest outcomes, with higher risk for disease severity and greater mortality. Metformin remains on the first line of the management of hyperglycemia in type 2 diabetes. Through its anti-inflammatory and immunomodulatory mechanisms, metformin appears as an opportunity to control the dysregulated cytokine storm secondary to SARS-CoV-2 infection. Recent studies point towards a potential protective role of metformin in the course of COVID-19, showing that current or previous treatment with metformin associates with better outcomes. | URI: | https://hdl.handle.net/10316/114176 | ISSN: | 10568727 | DOI: | 10.1016/j.jdiacomp.2022.108391 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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Metformin in SARS-CoV-2 infection A hidden path – from altered inflammation to reduced mortality. A review from the literature.pdf | 4.46 MB | Adobe PDF | View/Open |
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