Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/113939
Title: | Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities | Authors: | Trettel, Caio Dos Santos Pelozin, Bruno Rocha de Avila Barros, Marcelo Paes Bachi, André Luis Lacerda Braga, Pedro Gabriel Senger Momesso, César Miguel Furtado, Guilherme Eustáquio Valente, Pedro Afonso Oliveira, Edilamar Menezes Hogervorst, Eef Fernandes, Tiago A. |
Keywords: | skeletal muscle; exercise; exerkines; myokines; oxidative stress; inflammaging | Issue Date: | 2023 | Publisher: | Frontiers Media S.A. | Serial title, monograph or event: | Frontiers in Endocrinology | Volume: | 14 | Abstract: | Human beings lead largely sedentary lives. From an evolutionary perspective, such lifestyle is not beneficial to health. Exercise can promote many enabling pathways, particularly through circulating exerkines, to optimize individual health and quality of life. Such benefits might explain the protective effects of exercise against aging and noncommunicable diseases. Nevertheless, the miRNA-mediated molecular mechanisms and exerkine interorgan crosstalk that underlie the beneficial effects of exercise remain poorly understood. In this mini review, we focused on the exerkine, irisin, mainly produced by muscle contraction during adaptation to exercise and its beneficial effects on body homeostasis. Herein, the complex role of irisin in metabolism and inflammation is described, including its subsequent effects on thermogenesis through browning to control obesity and improve glycemic regulation for diabetes mellitus control, its potential to improve cognitive function (via brain derived neurotrophic factor), and its pathways of action and role in aging. | URI: | https://hdl.handle.net/10316/113939 | ISSN: | 1664-2392 | DOI: | 10.3389/fendo.2023.1106529 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais I&D CIDAF - Artigos em Revistas Internacionais FCDEF - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Irisin-An-antiinflammatory-exerkine-in-aging-and-redoxmediated-comorbiditiesFrontiers-in-Endocrinology.pdf | 770.29 kB | Adobe PDF | View/Open |
Page view(s)
75
checked on Oct 9, 2024
Download(s)
32
checked on Oct 9, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License