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Title: | Roadmap on nanomedicine for the central nervous system | Authors: | Ciofani, Gianni Campisi, Marco Mattu, Clara Kamm, Roger D. Chiono, Valeria Raynold, Aji Alex Moothedathu Freitas, João S. Redolfi Riva, Eugenio Micera, Silvestro Pucci, Carlotta Novio, Fernando Lorenzo, Julia Ruiz-Molina, Daniel Sierri, Giulia Re, Francesca Wunderlich, Hannah Kumari, Prachi Kozielski, Kristen L. Chami, Mounia Marino, Attilio Ferreira, Lino |
Keywords: | nanomedicines; introductions; central nervous system; roadmap; drug delivery; blood-brain barrier | Issue Date: | 2023 | Publisher: | Institute of Physics Publishing | Project: | AIRC under IG 2020—ID 24454 | Serial title, monograph or event: | JPhys Materials | Volume: | 6 | Issue: | 2 | Abstract: | In recent years, a great deal of effort has been undertaken with regards to treatment of pathologies at the level of the central nervous system (CNS). Here, the presence of the blood-brain barrier acts as an obstacle to the delivery of potentially effective drugs and makes accessibility to, and treatment of, the CNS one of the most significant challenges in medicine. In this Roadmap article, we present the status of the timeliest developments in the field, and identify the outstanding challenges and opportunities that exist. The format of the Roadmap, whereby experts in each discipline share their viewpoint and present their vision, reflects the dynamic and multidisciplinary nature of this research area, and is intended to generate dialogue and collaboration across traditional subject areas. It is stressed here that this article is not intended to act as a comprehensive review article, but rather an up-to-date and forward-looking summary of research methodologies pertaining to the treatment of pathologies at the level of the CNS. | URI: | https://hdl.handle.net/10316/113745 | ISSN: | 2515-7639 | DOI: | 10.1088/2515-7639/acab88 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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Roadmap-on-nanomedicine-for-the-central-nervous-systemJPhys-Materials.pdf | 6.53 MB | Adobe PDF | View/Open |
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