Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/113743
DC Field | Value | Language |
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dc.contributor.author | Cieri, Filippo | - |
dc.contributor.author | Cera, Nicoletta | - |
dc.contributor.author | Ritter, Aaron | - |
dc.contributor.author | Cordes, Dietmar | - |
dc.contributor.author | Caldwell, Jessica Zoe Kirkland | - |
dc.date.accessioned | 2024-02-29T10:20:38Z | - |
dc.date.available | 2024-02-29T10:20:38Z | - |
dc.date.issued | 2023-03-17 | - |
dc.identifier.issn | 2077-0383 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/113743 | - |
dc.description.abstract | Background: Olfaction impairment in aging is associated with increased anxiety. We explored this association in cognitively healthy controls (HCs), Mild Cognitive Impairment (MCI) and Parkinson’s disease (PD) patients. Both olfaction and anxiety have sex differences, therefore we also investigated these variances. Objectives: Investigate the association of olfaction with anxiety in three distinct clinical categories of aging, exploring the potential role of sex. Methods: 117 subjects (29 HCs, 43 MCI, and 45 PD patients) were assessed for olfaction and anxiety. We used regression models to determine whether B-SIT predicted anxiety and whether sex impacted that relationship. Results: Lower olfaction was related to greater anxiety traits in all groups (HCs: p = 0.015; MCI: p = 0.001 and PD: p = 0.038), significantly differed by sex. In fact, in HCs, for every unit increase in B-SIT, anxiety traits decreased by 7.63 in men (p = 0.009) and 1.5 in women (p = 0.225). In MCI patients for every unit increase in B-SIT, anxiety traits decreased by 1.19 in men (p = 0.048) and 3.03 in women (p = 0.0036). Finally, in PD patients for every unit increase in B-SIT, anxiety traits decreased by 1.73 in men (p = 0.004) and 0.41 in women (p = 0.3632). Discussion: Olfaction and anxiety are correlated in all three distinct diagnostic categories, but differently in men and women. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | F.C. is supported by the Women’s Alzheimer’s Movement at Cleveland Clinic. N.C. is supported by a grant from FCT (FCT-PTDC/PSI-GER/30520/2017; NORTE-01-0145-FEDER- 030520). D.C. is supported by a grant from the National Institute on Aging (RF1AG071566); an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number 5P20GM109025, and the Nevada Exploratory Alzheimer’s Disease Research Center (NVeADRC; P20-AG068053). In addition, research reported in this publication was supported in part by private grants from the Peter and Angela Dal Pezzo funds, from Lynn andWilliamWeidner, and from Stacie and Chuck Matthewson. J.Z.K.C. is supported by the Women’s Alzheimer’s Movement at Cleveland Clinic, and National Institute on Aging grants R01-AG074392 and P20-AG068053, and the COBRE funding: P20 GM109025. | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | olfaction | pt |
dc.subject | anxiety | pt |
dc.subject | sex difference | pt |
dc.subject | aging | pt |
dc.subject | Parkinson’s disease | pt |
dc.title | Olfaction and Anxiety Are Differently Associated in Men and Women in Cognitive Physiological and Pathological Aging | pt |
dc.type | article | - |
degois.publication.firstPage | 2338 | pt |
degois.publication.issue | 6 | pt |
degois.publication.title | Journal of Clinical Medicine | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/jcm12062338 | pt |
degois.publication.volume | 12 | pt |
dc.date.embargo | 2023-03-17 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.fulltext | Com Texto completo | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CIBIT - Coimbra Institute for Biomedical Imaging and Translational Research | - |
crisitem.author.orcid | 0000-0002-2702-8789 | - |
Appears in Collections: | I&D CIBIT - Artigos em Revistas Internacionais |
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Olfaction-and-Anxiety-Are-Differently-Associated-in-Men-and-Women-in-Cognitive-Physiological-and-Pathological-AgingJournal-of-Clinical-Medicine.pdf | 995.11 kB | Adobe PDF | View/Open |
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