Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/113278
DC Field | Value | Language |
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dc.contributor.author | Pessoa, João | - |
dc.contributor.author | Belew, Getachew D. | - |
dc.contributor.author | Barroso, Cristina | - |
dc.contributor.author | Egas, Conceição | - |
dc.contributor.author | Jones, John G. | - |
dc.date.accessioned | 2024-02-12T15:36:27Z | - |
dc.date.available | 2024-02-12T15:36:27Z | - |
dc.date.issued | 2023-04-27 | - |
dc.identifier.issn | 2072-6643 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/113278 | - |
dc.description.abstract | Describing diet-related effects on the gut microbiome is essential for understanding its interactions with fat and/or sugar-rich diets to promote obesity-related metabolic diseases. Here, we sequenced the V3-V4 hypervariable region of the bacterial 16S rRNA gene to study the composition and dynamics of the gut microbiome of adult mice fed diets rich in fat and/or sugar, at 9 and 18 weeks of diet. Under high-fat, high-sugar diet, the abundances of Tuzzerella and Anaerovorax were transiently increased at 9 weeks, while Lactobacillus remained elevated at 9 and 18 weeks. The same diet decreased the abundances of Akkermansia, Paludicola, Eisenbergiella, and Butyricicoccus at 9 and 18 weeks, while Intestinimonas and UCG-009 of the Butyricicoccaceae family responded only at 18 weeks. The high-fat diet decreased the abundances of UBA1819 at 9 weeks, and Gastranaerophilales, Clostridia UCG-014, and ASF356 at 9 and 18 weeks. Those of Marvinbryantia, Harryflintia, Alistipes, Blautia, Lachnospiraceae A2, Eubacterium coprostanoligenes group, and Eubacterium brachy group were lowered only at 18 weeks. Interestingly, these genera were not sensitive to the high-sugar diet. The mouse gut microbiome was differentially affected by diets rich in fat or fat and sugar. The differences observed at 9 and 18 weeks indicate a progressive microbiome response. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | This work was supported by the European Union’s Horizon 2020 Research and Innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 722619 (Project FOIE GRAS) and by the European Regional Development Fund (ERDF), through the COMPETE 2020— Operational Programme for Competitiveness and Internationalization and Portuguese national funds via FCT—Fundação para a Ciência e a Tecnologia, under the projects POCI-01-0145-FEDER-028147 (VISCERAL), POCI-01-0145-FEDER-022184 (GenomePT), UIDB/04539/2020, UIDP/04539/2020, and LA/P/0058/2020. | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | mouse model | pt |
dc.subject | diet | pt |
dc.subject | high-fat | pt |
dc.subject | high-sugar | pt |
dc.subject | gut microbiome | pt |
dc.subject | DNA sequencing | pt |
dc.subject | phylum | pt |
dc.subject | genus | pt |
dc.subject.mesh | Animals | pt |
dc.subject.mesh | Mice | pt |
dc.subject.mesh | Sugars | pt |
dc.subject.mesh | Dietary Fats | pt |
dc.subject.mesh | RNA, Ribosomal, 16S | pt |
dc.subject.mesh | Diet, High-Fat | pt |
dc.subject.mesh | Clostridiales | pt |
dc.subject.mesh | Clostridiaceae | pt |
dc.subject.mesh | Gastrointestinal Microbiome | pt |
dc.subject.mesh | Lactobacillales | pt |
dc.title | The Gut Microbiome Responds Progressively to Fat and/or Sugar-Rich Diets and Is Differentially Modified by Dietary Fat and Sugar | pt |
dc.type | article | - |
degois.publication.firstPage | 2097 | pt |
degois.publication.issue | 9 | pt |
degois.publication.title | Nutrients | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/nu15092097 | pt |
degois.publication.volume | 15 | pt |
dc.date.embargo | 2023-04-27 | * |
uc.date.periodoEmbargo | 0 | pt |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-7338-1938 | - |
crisitem.author.orcid | 0000-0002-2307-5414 | - |
crisitem.author.orcid | 0000-0002-3745-3885 | - |
Appears in Collections: | I&D CIBB - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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The-Gut-Microbiome-Responds-Progressively-to-Fat-andor-SugarRich-Diets-and-Is-Differentially-Modified-by-Dietary-Fat-and-SugarNutrients.pdf | 2.8 MB | Adobe PDF | View/Open |
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