Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/113136
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Silva, Rui | - |
dc.contributor.author | Colom, Helena | - |
dc.contributor.author | Bicker, Joana | - |
dc.contributor.author | Almeida, Anabela | - |
dc.contributor.author | Silva, Ana | - |
dc.contributor.author | Sales, Francisco | - |
dc.contributor.author | Santana, Isabel | - |
dc.contributor.author | Falcão, Amílcar | - |
dc.contributor.author | Fortuna, Ana | - |
dc.date.accessioned | 2024-02-06T12:38:50Z | - |
dc.date.available | 2024-02-06T12:38:50Z | - |
dc.date.issued | 2023-06-10 | - |
dc.identifier.issn | 1999-4923 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/113136 | - |
dc.description.abstract | Perampanel is a promising antiepileptic drug (AED) for refractory epilepsy treatment due to its innovative mechanism of action. This study aimed to develop a population pharmacokinetic (PopPK) model to be further used in initial dose optimization of perampanel in patients diagnosed with refractory epilepsy. A total of seventy-two plasma concentrations of perampanel obtained from forty-four patients were analyzed through a population pharmacokinetic approach by means of nonlinear mixed effects modeling (NONMEM). A one-compartment model with first-order elimination best described the pharmacokinetic profiles of perampanel. Interpatient variability (IPV) was entered on clearance (CL), while the residual error (RE) was modeled as proportional. The presence of enzyme-inducing AEDs (EIAEDs) and body mass index (BMI) were found as significant covariates for CL and volume of distribution (V), respectively. The mean (relative standard error) estimates for CL and V of the final model were 0.419 L/h (5.56%) and 29.50 (6.41%), respectively. IPV was 30.84% and the proportional RE was 6.44%. Internal validation demonstrated an acceptable predictive performance of the final model. A reliable population pharmacokinetic model was successfully developed, and it is the first enrolling real-life adults diagnosed with refractory epilepsy. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | POCI-01-0145-FEDER-030478 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | perampanel | pt |
dc.subject | epilepsy | pt |
dc.subject | population pharmacokinetics | pt |
dc.subject | NONMEM | pt |
dc.subject | therapeutic drug monitoring | pt |
dc.title | Population Pharmacokinetic Analysis of Perampanel in Portuguese Patients Diagnosed with Refractory Epilepsy | pt |
dc.type | article | - |
degois.publication.firstPage | 1704 | pt |
degois.publication.issue | 6 | pt |
degois.publication.title | Pharmaceutics | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/pharmaceutics15061704 | pt |
degois.publication.volume | 15 | pt |
dc.date.embargo | 2023-06-10 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-7515-1204 | - |
crisitem.author.orcid | 0000-0001-7500-1671 | - |
crisitem.author.orcid | 0000-0002-7394-3785 | - |
crisitem.author.orcid | 0000-0002-8114-9434 | - |
crisitem.author.orcid | 0000-0002-3854-6549 | - |
Appears in Collections: | I&D ICNAS - Artigos em Revistas Internacionais I&D CIBIT - Artigos em Revistas Internacionais FFUC- Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Population-Pharmacokinetic-Analysis-of-Perampanel-in-Portuguese-Patients-Diagnosed-with-Refractory-EpilepsyPharmaceutics.pdf | 6.11 MB | Adobe PDF | View/Open |
Page view(s)
96
checked on Oct 16, 2024
Download(s)
65
checked on Oct 16, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License