Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/112591
DC Field | Value | Language |
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dc.contributor.author | Adnane, Marouane | - |
dc.contributor.author | Khoumsi, Ahmed | - |
dc.contributor.author | Trovão, João Pedro F. | - |
dc.date.accessioned | 2024-02-01T12:00:25Z | - |
dc.date.available | 2024-02-01T12:00:25Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 1996-1073 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/112591 | - |
dc.description.abstract | Amyotrophic lateral sclerosis (ALS) is a severe and incurable neurodegenerative disease characterized by the progressive death of motor neurons, leading to paralysis and death. It is a rare disease characterized by high patient-to-patient heterogeneity, which makes its study arduous and complex. Extracellular vesicles (EVs) have emerged as important players in the development of ALS. Thus, ALS phenotype-expressing cells can spread their abnormal bioactive cargo through the secretion of EVs, even in distant tissues. Importantly, owing to their nature and composition, EVs’ formation and cargo can be exploited for better comprehension of this elusive disease and identification of novel biomarkers, as well as for potential therapeutic applications, such as those based on stem cell-derived exosomes. This review highlights recent advances in the identification of the role of EVs in ALS etiopathology and how EVs can be promising new therapeutic strategies. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | PTDC/BTM-ORG/0055/2021 | pt |
dc.relation | UIDB/04539/2020 | pt |
dc.relation | info:eu-repo/grantAgreement/UIDP/04539/2020 | pt |
dc.relation | LA/P/0058/2020 | pt |
dc.relation | DL57/2016/CP1448/CT0027 | pt |
dc.relation | 2022.13281.BD | pt |
dc.relation | CEECIND/00322/2017 | pt |
dc.relation | 2022.00011.CEECIND | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | amyotrophic lateral sclerosis | pt |
dc.subject | neurodegenerative diseases | pt |
dc.subject | extracellular vesicles | pt |
dc.subject | exosomes | pt |
dc.subject | miRNA | pt |
dc.subject | biomarkers | pt |
dc.title | Efficient Management of Energy Consumption of Electric Vehicles Using Machine Learning—A Systematic and Comprehensive Survey | pt |
dc.type | article | - |
degois.publication.firstPage | 4897 | pt |
degois.publication.issue | 13 | pt |
degois.publication.title | Energies | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/en16134897 | pt |
degois.publication.volume | 16 | pt |
dc.date.embargo | 2023-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology - CIBB | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology - Associate Laboratory | - |
crisitem.author.orcid | 0000-0002-0795-0901 | - |
Appears in Collections: | I&D INESCC - Artigos em Revistas Internacionais FCTUC Eng.Electrotécnica - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Recent-Advances-in-Extracellular-Vesicles-in-Amyotrophic-Lateral-Sclerosis-and-Emergent-PerspectivesCells.pdf | 1.01 MB | Adobe PDF | View/Open |
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