Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/112223
DC Field | Value | Language |
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dc.contributor.author | Santos, Joana Cristo | - |
dc.contributor.author | Henriques Abreu, Miguel | - |
dc.contributor.author | Santos, Miriam Seoane | - |
dc.contributor.author | Duarte, Hugo | - |
dc.contributor.author | Alpoim, Tiago | - |
dc.contributor.author | Próspero, Inês | - |
dc.contributor.author | Sousa, Susana | - |
dc.contributor.author | Abreu, Pedro Henriques | - |
dc.date.accessioned | 2024-01-25T11:30:32Z | - |
dc.date.available | 2024-01-25T11:30:32Z | - |
dc.date.issued | 2023-08-03 | - |
dc.identifier.issn | 1083-7159 | pt |
dc.identifier.issn | 1549-490X | pt |
dc.identifier.uri | https://hdl.handle.net/10316/112223 | - |
dc.description.abstract | Background: Positron emission tomography/computed tomography (PET/CT) has become in recent years a tool for breast cancer (BC) staging. However, its accuracy to detect bone metastases is classically considered inferior to bone scintigraphy (BS). The purpose of this work is to compare the effectiveness of bone metastases detection between PET/CT and BS. Materials and Methods: Prospective study of 410 female patients treated in a Comprehensive Cancer Center between 2014 and 2020 that performed PET/CT and BS for staging purposes. The image analysis was performed by 2 senior nuclear medicine physicians. The comparison was performed based on accuracy, sensitivity, and specificity on a patient and anatomical region level and was assessed using McNemar’s Test. An average ROC was calculated for the anatomical region analysis. Results: PET/CT presented higher values of accuracy and sensitivity (98.0% and 93.83%), surpassing BS (95.61% and 81.48%) in detecting bone disease. There was a significant difference in favor of PET/CT (sensitivity 93.83% vs. 81.48%), however, there is no significant difference in eliminating false positives (specificity 99.09% vs. 99.09%). PET/CT presented the highest accuracy and sensitivity values for most of the bone segments, only surpassed by BS for the cranium. There was a significant difference in favor of PET/CT in the upper limb, spine, thorax (sternum) and lower limb (pelvis and sacrum), and in favor of BS in the cranium. The ROC showed that PET/CT has a higher sensitivity and consistency across the bone segments. Conclusion: With the correct imaging protocol, PET/CT does not require BS for patients with BC staging. | pt |
dc.language.iso | eng | pt |
dc.publisher | Oxford University Press | pt |
dc.relation | UIDB/00326/2020 | pt |
dc.relation | UIDP/00326/2020 | pt |
dc.relation | Portuguese Institute of Oncology of Porto Francisco Gentil, EPE, Porto, Portugal under Grant CI-IPOP-76/2017-BI | pt |
dc.relation | FCT Grant 2020.05488.BD. | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Female | pt |
dc.subject.mesh | Positron Emission Tomography Computed Tomography | pt |
dc.subject.mesh | Positron-Emission Tomography | pt |
dc.subject.mesh | Prospective Studies | pt |
dc.subject.mesh | Sensitivity and Specificity | pt |
dc.subject.mesh | Fluorodeoxyglucose F18 | pt |
dc.subject.mesh | Breast Neoplasms | pt |
dc.subject.mesh | Bone Neoplasms | pt |
dc.title | Bone Metastases Detection in Patients with Breast Cancer: Does Bone Scintigraphy Add Information to PET/CT? | pt |
dc.type | article | - |
degois.publication.firstPage | e600 | pt |
degois.publication.lastPage | e605 | pt |
degois.publication.issue | 8 | pt |
degois.publication.title | Oncologist | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1093/oncolo/oyad087 | pt |
degois.publication.volume | 28 | pt |
dc.date.embargo | 2023-08-03 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairetype | article | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | CISUC- CENTRE FOR INFORMATICS AND SYSTEMS OF THE UNIVERSITY OF COIMBRA | - |
crisitem.author.researchunit | CISUC - Centre for Informatics and Systems of the University of Coimbra | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0002-7885-9697 | - |
crisitem.author.orcid | 0000-0002-9278-8194 | - |
Appears in Collections: | I&D CISUC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Bone Metastases Detection in Patients with Breast Cancer Does Bone Scintigraphy Add Information to PET CT.pdf | 698.27 kB | Adobe PDF | View/Open |
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