Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/112021
Title: Functional neuroimaging of responses to multiple sensory stimulations in newborns with perinatal asphyxia
Authors: Pinto, Carla R. 
Duarte, João V. 
Dinis, Alexandra
Duarte, Isabel C. 
Castelhano, João 
Pinto, Joana
Oliveira, Guiomar 
Castelo-Branco, Miguel 
Keywords: Newborn; functional magnetic resonance imaging (fMRI); functional near-infrared spectroscopy (fNIRS); perinatal asphyxia (PA); multiple sensory stimulations
Issue Date: 18-Sep-2023
Publisher: AME Publishing Company
Project: PTDC/DTP-PIC/6032/2014/POCI-01-0145- FEDER-016781 
Serial title, monograph or event: Translational Pediatrics
Volume: 12
Issue: 9
Abstract: Background: Functional neuroimaging can provide pathophysiological information in perinatal asphyxia (PA). However, fundamental unresolved questions remain related to the influence of neurovascular coupling (NVC) maturation on functional responses in early development. We aimed to probe the feasibility and compare the responses to multiple sensory stimulations in newborns with PA using functional magnetic resonance imaging (fMRI) and functional near-infrared spectroscopy (fNIRS). Methods: Responses to visual, auditory, and sensorimotor passive stimulation were measured with fMRI and fNIRS and compared in 18 term newborns with PA and six controls. Results: Most newborns exhibited a positive fMRI response during visual and sensorimotor stimulation, higher in the sensorimotor. An asymmetric pattern (negative in the left hemisphere) was observed in auditory stimulation. The fNIRS response most resembling the adult pattern (positive) in PA occurred during auditory stimulation, in which oxyhemoglobin (HbO) increased, and deoxyhemoglobin (HbR) decreased. Significative differences were found in the HbO and HbR profiles in newborns with PA compared to the controls, more evident in auditory stimulation. Positive correlations between the fMRI BOLD signal and at least one fNIRS channel (HbO) in all stimuli in newborns with PA were identified: the strongest was in the auditory (r=0.704) and the weakest in the sensorimotor (r=0.544); in more fNIRS channels, in the visual. Conclusions: Both techniques are feasible physiological assessment tools, suggesting a distinctive level of maturation in sensory and motor areas. Differences in fNIRS profiles in newborns with PA and controls and the fMRI-fNIRS relationship observed can encourage the fNIRS as a clinically emergent valuable tool.
URI: https://hdl.handle.net/10316/112021
ISSN: 2224-4344
DOI: 10.21037/tp-23-135
Rights: openAccess
Appears in Collections:I&D ICNAS - Artigos em Revistas Internacionais
I&D CIBIT - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais

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