Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/111989
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oliveira, Daniela | - |
dc.contributor.author | Fernandes, Sofia | - |
dc.contributor.author | Miguel, Isália | - |
dc.contributor.author | Fragoso, Sofia | - |
dc.contributor.author | Vaz, Fátima | - |
dc.date.accessioned | 2024-01-18T09:58:36Z | - |
dc.date.available | 2024-01-18T09:58:36Z | - |
dc.date.issued | 2023-08-23 | - |
dc.identifier.issn | 1718-7729 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/111989 | - |
dc.description.abstract | Risk-reducing surgeries are an option for cancer risk management in BRCA1/2 individuals. However, while adnexectomy is commonly recommended in breast cancer (BC) survivors, risk-reducing bilateral breast surgery (RRBBS) is controversial in ovarian cancer (OC) survivors due to relapse rates and mortality. Methods: We conducted a retrospective analysis of BRCA1/2- OC survivors, with OC as first cancer diagnosis. Results: Median age at OC diagnosis for the 69 BRCA1/2-OC survivors was 54 years. Median overall survival was 8 years, being significantly higher for BRCA2 patients than for BRCA1 patients (p = 0.011). Nine patients (13.2%) developed BC at a median age of 61 years. The mean overall BC-free survival was 15.5 years (median not reached). Eight patients (11.8%) underwent bilateral mastectomy (5 simultaneous with BC treatment; 3 RRBBS) at a median age of 56.5 years. The median time from OC to bilateral mastectomy/RRBBS was 5.5 years. Conclusions: This study adds evidence regarding a lower BC risk after BRCA1/2-OC and higher survival for BRCA2-OC patients. A comprehensive analysis of the competing risks of OC mortality and recurrence against the risk of BC should be individually addressed. Surgical BC risk management may be considered for longer BRCA1/2-OC disease-free survivors. Ultimately, these decisions should always be tailored to patients’ characteristics and preferences. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | ovarian cancer | pt |
dc.subject | breast cancer | pt |
dc.subject | hereditary cancer | pt |
dc.subject | BRCA | pt |
dc.subject | risk-reducing bilateral breast surgery | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Female | pt |
dc.subject.mesh | Middle Aged | pt |
dc.subject.mesh | Mastectomy | pt |
dc.subject.mesh | BRCA1 Protein | pt |
dc.subject.mesh | Retrospective Studies | pt |
dc.subject.mesh | BRCA2 Protein | pt |
dc.subject.mesh | Survivors | pt |
dc.subject.mesh | Cancer Survivors | pt |
dc.subject.mesh | Breast Neoplasms | pt |
dc.subject.mesh | Ovarian Neoplasms | pt |
dc.title | Is There a Role for Risk-Reducing Bilateral Breast Surgery in BRCA1/2 Ovarian Cancer Survivors? An Observational Study | pt |
dc.type | article | - |
degois.publication.firstPage | 7810 | pt |
degois.publication.lastPage | 7817 | pt |
degois.publication.issue | 9 | pt |
degois.publication.title | Current Oncology | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/curroncol30090567 | pt |
degois.publication.volume | 30 | pt |
dc.date.embargo | 2023-08-23 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairetype | article | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.orcid | 0000-0002-6636-7556 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Is-There-a-Role-for-RiskReducing-Bilateral-Breast-Surgery-in-BRCA12-Ovarian-Cancer-Survivors-An-Observational-StudyCurrent-Oncology.pdf | 492.08 kB | Adobe PDF | View/Open |
Page view(s)
19
checked on Jul 17, 2024
Download(s)
27
checked on Jul 17, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License