Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/111762
Title: | Biodistribution and intestinal inflammatory response following voluntary oral intake of silver nanoparticles by C57BL/6J mice | Authors: | Sousa, Adelaide Azevedo, Rui Costa, Vera Marisa Oliveira, Sara Preguiça, Inês Viana, Sofia Reis, Flávio Almeida, Agostinho Matafome, Paulo N. Dias-Pereira, Patrícia Carvalho, Félix Fernandes, Eduarda Freitas, Marisa da Silva |
Keywords: | Oral intake; Biodistribution; Subacute toxicity; Intestinal inflammation; NF-кB inflammatory pathway; Cytokines and chemokines | Issue Date: | Oct-2023 | Publisher: | Springer Nature | Project: | This work received support from national funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the projects UIBD/50006/2020 and UIDP/50006/2020 and from ‘Programa Operacional Competitividade e Internacionalização (COMPETE)(PTDC/ NAN-MAT/29248/2017-POCI‑01‑0145‑FEDER‑029248). This work was also supported by the Portuguese Foundation of Science and Technology (Strategic Projects UIDB//04539/2020, UIDP//04539/2020, and LA/P/0058/2020: CIBB). AS thanks FCT (Fundação para a Ciência e Tecnologia) and ESF (European Social Fund) through POCH (Programa Operacional Capital Humano) for her PhD grant reference SFRH/BD/150656/2020. MF acknowledges her contract under the Scientific Employment Stimulus—Individual Call (CEEC Individual) 2020.04126.CEECIND/CP1596/CT0006 and also to LAQV/ REQUIMTE her contract under the reference LA/P/0008/2020. VMC acknowledges the funding of FCT, IP, under Norma Transitória DL57/2016/CP1334/CT0006. | Serial title, monograph or event: | Archives of Toxicology | Volume: | 97 | Issue: | 10 | Abstract: | Silver nanoparticles (AgNP) are among the most widely commercialized nanomaterials globally, with applications in medicine and the food industry. Consequently, the increased use of AgNP in the food industry has led to an unavoidable rise in human exposure to these nanoparticles. Their widespread use raises concerns about potential hazards to human health, specifically their intestinal pro-inflammatory effects. Thus, the main objective of this study was to evaluate the biological effects of two subacute doses of 5 nm polyvinylpyrrolidone (PVP)-AgNP in C57BL/6J mice. One mg/kg body weight or 10 mg/kg bw was provided once a day for 14 days, using a new technology (HaPILLness) that allows voluntary, stress-free, and accurate oral dosing. It was observed that after oral ingestion, while AgNP is biodistributed throughout the entire organism, most of the ingested dose is excreted in the feces. The passage and accumulation of AgNP throughout the intestine instigated a prominent inflammatory response, marked by significant histological, vascular, and cellular transformations. This response was driven by the activation of the nuclear factor-кB (NF-кB) inflammatory pathway, ultimately leading to the generation of multiple cytokines and chemokines. | URI: | https://hdl.handle.net/10316/111762 | ISSN: | 0340-5761 1432-0738 |
DOI: | 10.1007/s00204-023-03558-5 | Rights: | openAccess |
Appears in Collections: | I&D ICBR - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Biodistribution-and-intestinal-inflammatory-response-following-voluntary-oral-intake-of-silver-nanoparticles-by-C57BL6J-miceArchives-of-Toxicology.pdf | 11.22 MB | Adobe PDF | View/Open |
Page view(s)
29
checked on Apr 24, 2024
Download(s)
1
checked on Apr 24, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License