Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/110978
Title: Multimodal assessment of the spatial correspondence between fNIRS and fMRI hemodynamic responses in motor tasks
Authors: Pereira, João 
Direito, Bruno 
Lührs, Michael
Castelo-Branco, Miguel 
Sousa, Teresa 
Issue Date: 8-Feb-2023
Publisher: Springer Nature
Project: CENTRO-01-0145- FEDER-000016 
PCIF/SSO/0082/2018 
DSAIPA/DS/0041/2020 
POCI-01-0145-FEDER-01642 
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP/04950/2020 
CENTRO-04-3559-FSE-000142 
PTDC/PSI-GER/30852/2017 
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB/04950/2020 
Serial title, monograph or event: Scientific Reports
Volume: 13
Issue: 1
Abstract: Functional near-infrared spectroscopy (fNIRS) provides a cost-efficient and portable alternative to functional magnetic resonance imaging (fMRI) for assessing cortical activity changes based on hemodynamic signals. The spatial and temporal underpinnings of the fMRI blood-oxygen-level-dependent (BOLD) signal and corresponding fNIRS concentration of oxygenated (HbO), deoxygenated (HbR), and total hemoglobin (HbT) measurements are still not completely clear. We aim to analyze the spatial correspondence between these hemodynamic signals, in motor-network regions. To this end, we acquired asynchronous fMRI and fNIRS recordings from 9 healthy participants while performing motor imagery and execution. Using this multimodal approach, we investigated the ability to identify motor-related activation clusters in fMRI data using subject-specific fNIRS-based cortical signals as predictors of interest. Group-level activation was found in fMRI data modeled from corresponding fNIRS measurements, with significant peak activation found overlapping the individually-defined primary and premotor motor cortices, for all chromophores. No statistically significant differences were observed in multimodal spatial correspondence between HbO, HbR, and HbT, for both tasks. This suggests the possibility of translating neuronal information from fMRI into an fNIRS motor-coverage setup with high spatial correspondence using both oxy and deoxyhemoglobin data, with the inherent benefits of translating fMRI paradigms to fNIRS in cognitive and clinical neuroscience.
URI: https://hdl.handle.net/10316/110978
ISSN: 2045-2322
DOI: 10.1038/s41598-023-29123-9
Rights: openAccess
Appears in Collections:I&D ICNAS - Artigos em Revistas Internacionais
I&D CIBIT - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais

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