Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/110895
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moreira, Paula I. | - |
dc.contributor.author | Zhu, Xiongwei | - |
dc.contributor.author | Liu, Quan | - |
dc.contributor.author | Honda, Kazuhiro | - |
dc.contributor.author | Siedlak, Sandra L | - |
dc.contributor.author | Harris, Peggy L. R. | - |
dc.contributor.author | Smith, Mark A. | - |
dc.contributor.author | Perry, George | - |
dc.date.accessioned | 2023-11-27T10:29:26Z | - |
dc.date.available | 2023-11-27T10:29:26Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0716-9760 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/110895 | - |
dc.description.abstract | Oxidative stress occurs early in the progression of Alzheimer disease, significantly before the development of the pathologic hallmarks, neurofibrillary tangles and senile plaques. In the first stage of development of the disease, amyloid-beta deposition and hyperphosphorylated tau function as compensatory responses and downstream adaptations to ensure that neuronal cells do not succumb to oxidative damage. These findings suggest that Alzheimer disease is associated with a novel balance in oxidant homeostasis. | pt |
dc.language.iso | eng | pt |
dc.publisher | Springer Nature | pt |
dc.relation | National Institutes of Health | pt |
dc.relation | Alzheimer’s Association | pt |
dc.relation | Philip Morris USA. | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Alzheimer disease | pt |
dc.subject | antioxidant therapy | pt |
dc.subject | mitochondria | pt |
dc.subject | oxidative stress | pt |
dc.subject | redox metals | pt |
dc.subject.mesh | Adaptation, Physiological | pt |
dc.subject.mesh | Alzheimer Disease | pt |
dc.subject.mesh | Amyloid beta-Peptides | pt |
dc.subject.mesh | Disease Progression | pt |
dc.subject.mesh | Glycogen Synthase Kinase 3 | pt |
dc.subject.mesh | Homeostasis | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Neurons | pt |
dc.subject.mesh | Oxidative Phosphorylation | pt |
dc.subject.mesh | Oxidative Stress | pt |
dc.subject.mesh | Protein Serine-Threonine Kinases | pt |
dc.title | Compensatory responses induced by oxidative stress in Alzheimer disease | pt |
dc.type | article | - |
degois.publication.firstPage | 7 | pt |
degois.publication.lastPage | 13 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Biological Research | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.4067/s0716-97602006000100002 | pt |
degois.publication.volume | 39 | pt |
dc.date.embargo | 2006-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0001-5177-6747 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Compensatory-responses-induced-by-oxidative-stress-in-Alzheimer-diseaseBiological-Research.pdf | 550.14 kB | Adobe PDF | View/Open |
Page view(s)
37
checked on May 8, 2024
Download(s)
13
checked on May 8, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License