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https://hdl.handle.net/10316/110175
Title: | Expressão da caderina na discondroplasia tibial | Other Titles: | Cadherin expression in the tibial dyschondroplasia | Authors: | Capela e Silva, F. Lamy, E. Pereira, A. Reis, J. C. Potes, J.C. Cabrita, A. S. |
Keywords: | tibial dyschondroplasia; cadherin; immunohistochemistry | Issue Date: | 2010 | Publisher: | Universidade de Minas Gerais | Serial title, monograph or event: | Arquivo Brasileiro de Medicina Veterinaria e Zootecnia | Volume: | 62 | Issue: | 1 | Abstract: | By immunohistochemistry the expression of a pan-cadherin antibody that recognizes a wide variety of cadherins in chondrocytes from normal and tibial dyschondroplasia (TD) growth plates was compared. Surprisingly, an upregulated expression that was not expected in TD lesion chondrocytes was observed. The reason for this apparent upregulation is not clear. The increased expression may simply be due to the particular phenotype of lesion chondrocytes, and cadherin may be involved in apoptosis of chondrocytes of TD lesion. Another possibility, is that a low level of calcium in the lesion may be responsible for the observed upregulation. The results of the present study suggest that the formation of the dyschondroplastic lesion is not merely due to the impaired terminal differentiation of lesion chondrocytes and that other mechanisms are probably involved in TD etiology. Further studies will be necessary to provide insight into the precise nature of the condition. | URI: | https://hdl.handle.net/10316/110175 | ISSN: | 0102-0935 | DOI: | 10.1590/S0102-09352010000100030 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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Cadherin-expression-in-the-tibial-dyschondroplasiaArquivo-Brasileiro-de-Medicina-Veterinaria-e-Zootecnia.pdf | 3.28 MB | Adobe PDF | View/Open |
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