Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/109883
DC Field | Value | Language |
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dc.contributor.author | Duarte, Ana I. | - |
dc.contributor.author | Moreira, Paula I. | - |
dc.contributor.author | Oliveira, C. R. | - |
dc.date.accessioned | 2023-11-03T10:11:49Z | - |
dc.date.available | 2023-11-03T10:11:49Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 2090-2204 | pt |
dc.identifier.issn | 2090-2212 | pt |
dc.identifier.uri | http://hdl.handle.net/10316/109883 | - |
dc.description.abstract | Insulin signaling in central nervous system (CNS) has emerged as a novel field of research since decreased brain insulin levels and/or signaling were associated to impaired learning, memory, and age-related neurodegenerative diseases. Thus, besides its well-known role in longevity, insulin may constitute a promising therapy against diabetes- and age-related neurodegenerative disorders. More interestingly, insulin has been also faced as the potential missing link between diabetes and aging in CNS, with Alzheimer's disease (AD) considered as the "brain-type diabetes." In fact, brain insulin has been shown to regulate both peripheral and central glucose metabolism, neurotransmission, learning, and memory and to be neuroprotective. And a future challenge will be to unravel the complex interactions between aging and diabetes, which, we believe, will allow the development of efficient preventive and therapeutic strategies to overcome age-related diseases and to prolong human "healthy" longevity. Herewith, we aim to integrate the metabolic, neuromodulatory, and neuroprotective roles of insulin in two age-related pathologies: diabetes and AD, both in terms of intracellular signaling and potential therapeutic approach. | pt |
dc.language.iso | eng | pt |
dc.publisher | Hindawi | pt |
dc.relation | FCT, Project PTDC/SAU-TOX/117481/2010 | pt |
dc.relation | Programa de Estímulo à Investigação da Faculdade de Medicina, Universidade de Coimbra, Portugal (PMADSC/2011) | pt |
dc.relation | SFRH/BPD/26872/2006 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.title | Insulin in central nervous system: more than just a peripheral hormone | pt |
dc.type | article | - |
degois.publication.firstPage | 384017 | pt |
degois.publication.lastPage | 21 | pt |
degois.publication.title | Journal of Aging Research | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1155/2012/384017 | pt |
degois.publication.volume | 2012 | pt |
dc.date.embargo | 2012-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0001-5177-6747 | - |
crisitem.author.orcid | 0000-0001-6942-4328 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Insulin-in-central-nervous-system-More-than-just-a-peripheral-hormoneJournal-of-Aging-Research.pdf | 1.41 MB | Adobe PDF | View/Open |
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This item is licensed under a Creative Commons License