Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/109752
DC Field | Value | Language |
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dc.contributor.author | Mascarenhas-Melo, Filipa | - |
dc.contributor.author | Sereno, José | - |
dc.contributor.author | Teixeira-Lemos, Edite | - |
dc.contributor.author | Marado, Daniela | - |
dc.contributor.author | Palavra, Filipe | - |
dc.contributor.author | Pinto, Rui | - |
dc.contributor.author | Rocha-Pereira, Petronila | - |
dc.contributor.author | Teixeira, Frederico | - |
dc.contributor.author | Reis, Flávio | - |
dc.date.accessioned | 2023-10-25T09:47:53Z | - |
dc.date.available | 2023-10-25T09:47:53Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0962-9351 | pt |
dc.identifier.issn | 1466-1861 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/109752 | - |
dc.description.abstract | To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles. Patients with cardiovascular risk factors (n = 169) and control subjects (n = 73) were divided into 2 subgroups, one of normal HDL-c and the other of low HDL-c levels. The following data was analyzed: BP, BMI, waist circumference and serum glucose Total-c, TGs, LDL-c, oxidized LDL, total HDL-c and subpopulations (small, intermediate, and large), paraoxonase-1 (PON1) activity, hsCRP, uric acid, TNF- α , adiponectin, VEGF, and iCAM1. In the control subgroup with low HDL-c levels, significantly higher values of BP and TGs and lower values of PON1 activity and adiponectin were found, versus control normal HDL-c subgroup. However, differences in patients' subgroups were clearly more pronounced. Indeed, low HDL-c subgroup presented increased HbA1c, TGs, non-HDL-c, Ox-LDL, hsCRP, VEGF, and small HDL-c and reduced adiponectin and large HDL. In addition, Ox-LDL, large-HDL-c, and adiponectin presented interesting correlations with classical and nonclassical markers, mainly in the normal HDL-c patients' subgroup. In conclusion, despite LDL-c average levels, low HDL-c concentrations seem to be associated with a poor cardiometabolic profile in a population with cardiovascular risk factors, which is better evidenced by traditional and nontraditional CV biomarkers, including Ox-LDL, large HDL-c, and adiponectin. | pt |
dc.language.iso | eng | pt |
dc.publisher | Hindawi | pt |
dc.relation | SFRH/ BD/65483/2009 | pt |
dc.relation | Strategic Project (PEst-C/SAU/UI3282/ 2011) | pt |
dc.relation | COMPETE | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject.mesh | Adiponectin | pt |
dc.subject.mesh | Adult | pt |
dc.subject.mesh | Aged | pt |
dc.subject.mesh | Aryldialkylphosphatase | pt |
dc.subject.mesh | Biomarkers | pt |
dc.subject.mesh | Blood Glucose | pt |
dc.subject.mesh | Blood Pressure | pt |
dc.subject.mesh | Body Mass Index | pt |
dc.subject.mesh | C-Reactive Protein | pt |
dc.subject.mesh | Cardiovascular Diseases | pt |
dc.subject.mesh | Case-Control Studies | pt |
dc.subject.mesh | Cholesterol, HDL | pt |
dc.subject.mesh | Female | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Inflammation | pt |
dc.subject.mesh | Intercellular Adhesion Molecule-1 | pt |
dc.subject.mesh | Lipid Metabolism | pt |
dc.subject.mesh | Lipoproteins, LDL | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Middle Aged | pt |
dc.subject.mesh | Oxygen | pt |
dc.subject.mesh | Risk Factors | pt |
dc.subject.mesh | Tumor Necrosis Factor-alpha | pt |
dc.subject.mesh | Uric Acid | pt |
dc.subject.mesh | Vascular Endothelial Growth Factor A | pt |
dc.subject.mesh | Waist Circumference | pt |
dc.subject.mesh | Gene Expression Regulation | pt |
dc.title | Implication of low HDL-c levels in patients with average LDL-c levels: a focus on oxidized LDL, large HDL subpopulation, and adiponectin | pt |
dc.type | article | - |
degois.publication.firstPage | 612038 | pt |
degois.publication.lastPage | 12 | pt |
degois.publication.title | Mediators of Inflammation | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1155/2013/612038 | pt |
degois.publication.volume | 2013 | pt |
dc.date.embargo | 2013-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.orcid | 0000-0003-0786-6280 | - |
crisitem.author.orcid | 0000-0002-6346-8319 | - |
crisitem.author.orcid | https://orcid.org/0000-0002-2165-130X | - |
crisitem.author.orcid | 0000-0002-2601-0923 | - |
crisitem.author.orcid | 0000-0003-3401-9554 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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Implication-of-low-HDLc-levels-in-patients-with-average-LDLc-levels-A-focus-on-oxidized-LDL-large-HDL-subpopulation-and-adiponectinMediators-of-Inflammation.pdf | 4.37 MB | Adobe PDF | View/Open |
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