Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/109731
DC Field | Value | Language |
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dc.contributor.author | Mascarenhas-Melo, Filipa | - |
dc.contributor.author | Sereno, José | - |
dc.contributor.author | Lemos, Edite Teixeira de | - |
dc.contributor.author | Ribeiro, Sandra | - |
dc.contributor.author | Rocha-Pereira, Petronila | - |
dc.contributor.author | Cotterill, Ethan | - |
dc.contributor.author | Teixeira, Frederico | - |
dc.contributor.author | Reis, Flávio | - |
dc.date.accessioned | 2023-10-24T11:52:22Z | - |
dc.date.available | 2023-10-24T11:52:22Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0278-0240 | pt |
dc.identifier.issn | 1875-8630 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/109731 | - |
dc.description.abstract | To evaluate the effect of gender and menopause in cardiovascular risk (CVR) in a healthy population based on both classical and nontraditional markers. Methods. 56 men and 68 women (48 pre- and 20 postmenopause) were enrolled in the study. The following markers were analyzed: blood pressure (BP), body mass index (BMI), waist circumference (WC), glucose, total cholesterol (total-c), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-c), oxidized-LDL (Ox-LDL), HDL-c and subpopulations, paraoxonase-1 activity, hsCRP, uric acid, tumor necrosis factor alpha (TNF-𝛼), adiponectin, vascular endothelial growth factor (VEGF), and intercellular adhesion molecular 1 (ICAM1). Results. Relative to the women, men present significantly increased BMI,WC, BP, glucose, total-c, TGs, LDL-c, Ox-LDL, uric acid, and TNF-𝛼 and reduced adiponectin and total and large HDL-c. The protective profile of women is lost after menopause with a significantly increased BMI, WC, BP, glucose, LDL-c, Ox- LDL, hsCRP, and VEGF and decreased total and large HDL-c. Significant correlations were found in women population and in postmenopausal women between Ox-LDL and total, large, and small HDL-c and between TNF-𝛼 and total, large, and small HDLc, LDL-c, and Ox-LDL. Conclusions. Men present higher CVR than women who lost protection after menopause, evidenced by nontraditional markers, including Ox-LDL and HDL subpopulations. | pt |
dc.language.iso | eng | pt |
dc.publisher | Hindawi | pt |
dc.relation | SFRH/BD/ 65483/2009 | pt |
dc.relation | PEst-C/SAU/UI3282/ 2011 | pt |
dc.relation | COMPETE | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject.mesh | Adult | pt |
dc.subject.mesh | Aged | pt |
dc.subject.mesh | Aryldialkylphosphatase | pt |
dc.subject.mesh | Biomarkers | pt |
dc.subject.mesh | Cardiovascular Diseases | pt |
dc.subject.mesh | Female | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Lipoproteins, HDL | pt |
dc.subject.mesh | Lipoproteins, LDL | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Middle Aged | pt |
dc.subject.mesh | Postmenopause | pt |
dc.subject.mesh | Risk Factors | pt |
dc.subject.mesh | Young Adult | pt |
dc.title | Markers of increased cardiovascular risk in postmenopausal women: focus on oxidized-LDL and HDL subpopulations | pt |
dc.type | article | - |
degois.publication.firstPage | 85 | pt |
degois.publication.lastPage | 96 | pt |
degois.publication.issue | 2 | pt |
degois.publication.title | Disease Markers | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1155/2013/724706 | pt |
degois.publication.volume | 35 | pt |
dc.date.embargo | 2013-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.orcid | 0000-0003-0786-6280 | - |
crisitem.author.orcid | 0000-0002-6346-8319 | - |
crisitem.author.orcid | 0000-0002-2601-0923 | - |
crisitem.author.orcid | 0000-0003-3401-9554 | - |
Appears in Collections: | FCTUC Matemática - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Markers-of-increased-cardiovascular-risk-in-postmenopausal-women-Focus-on-oxidizedLDL-and-HDL-subpopulationsDisease-Markers.pdf | 5.44 MB | Adobe PDF | View/Open |
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