Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/109721
DC Field | Value | Language |
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dc.contributor.author | Melo, Filipa Mascarenhas | - |
dc.contributor.author | Marado, Daniela | - |
dc.contributor.author | Palavra, Filipe | - |
dc.contributor.author | Sereno, José | - |
dc.contributor.author | Coelho, Álvaro | - |
dc.contributor.author | Pinto, Rui | - |
dc.contributor.author | Lemos, Edite Teixeira de | - |
dc.contributor.author | Teixeira, Frederico | - |
dc.contributor.author | Reis, Flávio | - |
dc.date.accessioned | 2023-10-24T10:12:40Z | - |
dc.date.available | 2023-10-24T10:12:40Z | - |
dc.date.issued | 2013-04-09 | - |
dc.identifier.issn | 1475-2840 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/109721 | - |
dc.description.abstract | Background: The aim of this study is to evaluate the effect of gender and menopause in cardiometabolic risk in a type 2 diabetes mellitus (T2DM) population, based on classical and non-traditional markers. Methods: Seventy four volunteers and 110 T2DM patients were enrolled in the study. Anthropometric data, blood pressure, body mass index (BMI), waist circumference (WC) and the following serum markers were analyzed: glucose, Total-c, TGs, LDL-c, Oxidized-LDL, total HDL-c and large and small HDL-c subpopulations, paraoxonase 1 activity, hsCRP, uric acid, TNF-α, adiponectin and VEGF. Results: Non-diabetic women, compared to men, presented lower glycemia, WC, small HDL-c, uric acid, TNF-α and increased large HDL-c. Diabetes abrogates the protective effect of female gender, since diabetic women showed increased BMI, WC, small HDL-c, VEGF, uric acid, TNF-α and hsCRP, as well as reduced adiponectin, when compared with non-diabetic. In diabetic females, but not in males, WC is directly and significantly associated with TNF-α, VEGF, hsCRP and uric acid; TNF-α is directly associated with VEGF and hsCRP, and inversely with adiponectin. Postmenopausal females presented a worsen cardiometabolic profile, viewed by the increased WC, small HDL-c, VEGF, uric acid, TNF-α and hsCRP. In this population, WC is directly and significantly associated with TNF-α, VEGF, hsCRP; TNF-α is directly associated with VEGF; and uric acid is inversely associated with large HDL-c and hsCRP with adiponectin, also inversely. Conclusions: Diabetes abrogates the protective effect of gender on non-diabetic women, and postmenopausal diabetic females presented worsen cardiometabolic risk, including a more atherogenic lipid sketch and a proinflammatory and pro-angiogenic profile. The classical cardiovascular risk factors (CVRFs) fail to completely explain these differences, which are better clarified using “non-traditional” factors, such as HDL-c subpopulations, rather than total HDL-c content, and markers of inflammation and angiogenesis, namely TNF-α, hsCRP, uric acid and VEGF. Multi-therapeutic intervention, directed to obesity, atherogenic lipid particles and inflammatory mediators is advisory in order to efficiently prevent the serious diabetic cardiovascular complications. | pt |
dc.language.iso | eng | pt |
dc.publisher | Springer Nature | pt |
dc.relation | PhD Grant (SFRH/BD/65483/2009) | pt |
dc.relation | PEst-C/SAU/UI3282/2011 | pt |
dc.relation | COMPETE | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Diabetes | pt |
dc.subject | Gender | pt |
dc.subject | HDL-c subpopulations | pt |
dc.subject | Markers of cardiovascular risk | pt |
dc.subject | Menopause | pt |
dc.subject.mesh | Blood Glucose | pt |
dc.subject.mesh | Cardiovascular Diseases | pt |
dc.subject.mesh | Diabetes Mellitus, Type 2 | pt |
dc.subject.mesh | Female | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Middle Aged | pt |
dc.subject.mesh | Postmenopause | pt |
dc.subject.mesh | Risk Factors | pt |
dc.subject.mesh | Waist Circumference | pt |
dc.subject.mesh | Body Mass Index | pt |
dc.subject.mesh | Sex Characteristics | pt |
dc.title | Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women | pt |
dc.type | article | - |
degois.publication.firstPage | 61 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Cardiovascular Diabetology | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1186/1475-2840-12-61 | pt |
degois.publication.volume | 12 | pt |
dc.date.embargo | 2013-04-09 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.orcid | 0000-0003-0786-6280 | - |
crisitem.author.orcid | https://orcid.org/0000-0002-2165-130X | - |
crisitem.author.orcid | 0000-0002-6346-8319 | - |
crisitem.author.orcid | 0000-0002-2601-0923 | - |
crisitem.author.orcid | 0000-0003-3401-9554 | - |
Appears in Collections: | I&D IBILI - Artigos em Revistas Internacionais I&D IBILI - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Diabetes-abrogates-sex-differences-and-aggravates-cardiometabolic-risk-in-postmenopausal-womenCardiovascular-Diabetology.pdf | 1.06 MB | Adobe PDF | View/Open |
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This item is licensed under a Creative Commons License