Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/109681
DC Field | Value | Language |
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dc.contributor.author | Alvarado-Rojas, C | - |
dc.contributor.author | Valderrama, M | - |
dc.contributor.author | Fouad-Ahmed, A | - |
dc.contributor.author | Feldwisch-Drentrup, H | - |
dc.contributor.author | Ihle, M | - |
dc.contributor.author | Teixeira, C. A. | - |
dc.contributor.author | Sales, F. | - |
dc.contributor.author | Schulze-Bonhage, A | - |
dc.contributor.author | Adam, C | - |
dc.contributor.author | Dourado, A. | - |
dc.contributor.author | Charpier, S | - |
dc.contributor.author | Navarro, V | - |
dc.contributor.author | Le Van Quyen, M | - |
dc.date.accessioned | 2023-10-20T11:31:59Z | - |
dc.date.available | 2023-10-20T11:31:59Z | - |
dc.date.issued | 2014-04-01 | - |
dc.identifier.issn | 2045-2322 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/109681 | - |
dc.description.abstract | Recent evidence suggests that some seizures are preceded by preictal changes that start from minutes to hours before an ictal event. Nevertheless an adequate statistical evaluation in a large database of continuous multiday recordings is still missing. Here, we investigated the existence of preictal changes in long-term intracranial recordings from 53 patients with intractable partial epilepsy (in total 531 days and 558 clinical seizures). We describe a measure of brain excitability based on the slow modulation of high-frequency gamma activities (40-140 Hz) in ensembles of intracranial contacts. In prospective tests, we found that this index identified preictal changes at levels above chance in 13.2% of the patients (7/53), suggesting that results may be significant for the whole group (p < 0.05). These results provide a demonstration that preictal states can be detected prospectively from EEG data. They advance understanding of the network dynamics leading to seizure and may help develop novel seizure prediction algorithms. | pt |
dc.description.sponsorship | This work was supported by the European Union-FP7 Project EPILEPSIAE (Evolving Platform for Improving Living Expectation of Subjects Suffering from IctAl Events, Grant No 211713) and by the program Investissements d’avenir ANR-10-IAIHU-06, France. C.A.R thanks the Administrative Department for Science, Technology and Innovation (COLCIENCIAS), Colombia, for financial support. V.N. was supported by Contrat d’Interface INSERM. | pt |
dc.language.iso | por | pt |
dc.publisher | Springer Nature | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject.mesh | Adolescent | pt |
dc.subject.mesh | Adult | pt |
dc.subject.mesh | Brain Waves | pt |
dc.subject.mesh | Child | pt |
dc.subject.mesh | Child, Preschool | pt |
dc.subject.mesh | Epilepsies, Partial | pt |
dc.subject.mesh | Female | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Middle Aged | pt |
dc.subject.mesh | Young Adult | pt |
dc.subject.mesh | Electroencephalography | pt |
dc.title | Slow modulations of high-frequency activity (40-140-Hz) discriminate preictal changes in human focal epilepsy | pt |
dc.type | article | - |
degois.publication.firstPage | 4545 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Scientific Reports | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1038/srep04545 | pt |
degois.publication.volume | 4 | pt |
dc.date.embargo | 2014-04-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | pt | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CISUC - Centre for Informatics and Systems of the University of Coimbra | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0001-9396-1211 | - |
Appears in Collections: | I&D CISUC - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Slow-modulations-of-highfrequency-activity-40140-Hz-discriminate-preictal-changes-in-human-focal-epilepsyScientific-Reports.pdf | 2.06 MB | Adobe PDF | View/Open |
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