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https://hdl.handle.net/10316/109079
Title: | Human settlement history between Sunda and Sahul: a focus on East Timor (Timor-Leste) and the Pleistocenic mtDNA diversity | Authors: | Gomes, Sibylle M. Bodner, Martin Souto, Luís Zimmermann, Bettina Huber, Gabriela Strobl, Christina Röck, Alexander W. Achilli, Alessandro Olivieri, Anna Torroni, Antonio Corte Real, Francisco Parson, Walther |
Keywords: | East Timor (Timor-Leste); Island Southeast Asia; Mitochondrial DNA; mtDNA haplogroup P; Human migration; First settlers; Population genetics; Forensic mtDNA analysis; Next generation sequencing; Ion Torrent PGM | Issue Date: | 14-Feb-2015 | Publisher: | Springer Nature | Project: | PTDC/CS-ANT/108558/ 2008 FCT fellowship SFRH/BD/63165/2009 Austrian Science Fund (FWF) [L397] and [P22880-B12]; European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 285487 intramural funding program of the Medical University Innsbruck for young scientists MUI-START, Project 2013042025 Theodor Körner Fonds zur Förderung von Wissenschaft und Kunst |
Serial title, monograph or event: | BMC Genomics | Volume: | 16 | Issue: | 1 | Abstract: | Background: Distinct, partly competing, “waves” have been proposed to explain human migration in(to) today’s Island Southeast Asia and Australia based on genetic (and other) evidence. The paucity of high quality and high resolution data has impeded insights so far. In this study, one of the first in a forensic environment, we used the Ion Torrent Personal Genome Machine (PGM) for generating complete mitogenome sequences via stand-alone massively parallel sequencing and describe a standard data validation practice. Results: In this first representative investigation on the mitochondrial DNA (mtDNA) variation of East Timor (Timor-Leste) population including >300 individuals, we put special emphasis on the reconstruction of the initial settlement, in particular on the previously poorly resolved haplogroup P1, an indigenous lineage of the Southwest Pacific region. Our results suggest a colonization of southern Sahul (Australia) >37 kya, limited subsequent exchange, and a parallel incubation of initial settlers in northern Sahul (New Guinea) followed by westward migrations <28 kya. Conclusions: The temporal proximity and possible coincidence of these latter dispersals, which encompassed autochthonous haplogroups, with the postulated “later” events of (South) East Asian origin pinpoints a highly dynamic migratory phase. | URI: | https://hdl.handle.net/10316/109079 | ISSN: | 1471-2164 | DOI: | 10.1186/s12864-014-1201-x | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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