Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/108706
DC FieldValueLanguage
dc.contributor.authorSilva, Gabriela Jorge da-
dc.contributor.authorDomingues, Sara-
dc.date.accessioned2023-09-08T10:48:56Z-
dc.date.available2023-09-08T10:48:56Z-
dc.date.issued2016-08-23-
dc.identifier.issn2076-2607pt
dc.identifier.urihttps://hdl.handle.net/10316/108706-
dc.description.abstractHorizontal gene transfer (HGT) is a driving force to the evolution of bacteria. The fast emergence of antimicrobial resistance reflects the ability of genetic adaptation of pathogens. Acinetobacter baumannii has emerged in the last few decades as an important opportunistic nosocomial pathogen, in part due to its high capacity of acquiring resistance to diverse antibiotic families, including to the so-called last line drugs such as carbapenems. The rampant selective pressure and genetic exchange of resistance genes hinder the effective treatment of resistant infections. A. baumannii uses all the resistance mechanisms to survive against carbapenems but production of carbapenemases are the major mechanism, which may act in synergy with others. A. baumannii appears to use all the mechanisms of gene dissemination. Beyond conjugation, the mostly reported recent studies point to natural transformation, transduction and outer membrane vesicles-mediated transfer as mechanisms that may play a role in carbapenemase determinants spread. Understanding the genetic mobilization of carbapenemase genes is paramount in preventing their dissemination. Here we review the carbapenemases found in A. baumannii and present an overview of the current knowledge of contributions of the various HGT mechanisms to the molecular epidemiology of carbapenem resistance in this relevant opportunistic pathogen.pt
dc.language.isoengpt
dc.publisherMDPIpt
dc.relationUID/NEU/04539/2013pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subjectAcinetobacterpt
dc.subjectoxacillinasespt
dc.subjectmetallo- -lactamasespt
dc.subjectconjugationpt
dc.subjecttransductionpt
dc.subjectnatural transformationpt
dc.subjectouter-membrane vesicles-mediated transferpt
dc.subjectepidemiologypt
dc.subjectantimicrobial resistancept
dc.titleInsights on the Horizontal Gene Transfer of Carbapenemase Determinants in the Opportunistic Pathogen Acinetobacter baumanniipt
dc.typearticle-
degois.publication.firstPage29pt
degois.publication.issue3pt
degois.publication.titleMicroorganismspt
dc.peerreviewedyespt
dc.identifier.doi10.3390/microorganisms4030029pt
degois.publication.volume4pt
dc.date.embargo2016-08-23*
uc.date.periodoEmbargo0pt
item.grantfulltextopen-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairetypearticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextCom Texto completo-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0002-7479-8540-
crisitem.author.orcid0000-0002-8879-5113-
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
FFUC- Artigos em Revistas Internacionais
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