Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/108523
Title: | Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles | Authors: | Conceição, Mariana Mendonça, Liliana Nóbrega, Clévio Gomes, Célia Costa, Pedro Hirai, Hirokazu Moreira, João Nuno Lima, Maria C. Pedroso de Manjunath, N. Almeida, Luís Pereira de |
Issue Date: | Mar-2016 | Publisher: | Elsevier | Project: | PTDC/SAU-FAR/116535/2010 E-Rare4/0003/2012 PEst-C/SAU/LA0001/2013-2014 CENTRO-07-ST24-FEDER-002002,002006,002008 andbythestrategicprojectUID/ NEU/04539/2013 |
Serial title, monograph or event: | Data in Brief | Volume: | 6 | Abstract: | In a clinical setting, where multiple administrations of the therapeutic agent are usually required to improve the therapeutic outcome, it is crucial to assess the immunogenicity of the administered nanoparticles. In this data work, we investigated the safety profile of the repeated intravenous administration of brain-targeted stable nucleic acid lipid particles (RVG-9r-targeted SNALPs). To evaluate local activation of the immune system, we performed analysis of mouse tissue homogenates and sections from cerebellum. To investigate peripheral activation of the immune system, we used serum of mice that were intravenously injected with RVG-9r-targeted SNALPs. These data are related and were discussed in the accompanying research article entitled "Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype" (Conceição et al., in press) [1]. | URI: | https://hdl.handle.net/10316/108523 | ISSN: | 2352-3409 | DOI: | 10.1016/j.dib.2016.01.017 | Rights: | openAccess |
Appears in Collections: | I&D IBILI - Artigos em Revistas Internacionais FFUC- Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles.pdf | 2.02 MB | Adobe PDF | View/Open |
Page view(s)
53
checked on Apr 24, 2024
Download(s)
8
checked on Apr 24, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License