Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/108383
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Machado, Ana Rita | - |
dc.contributor.author | Pereira, Andreia Carvalho | - |
dc.contributor.author | Ferreira, Fábio | - |
dc.contributor.author | Ferreira, Sónia | - |
dc.contributor.author | Quendera, Bruno | - |
dc.contributor.author | Silva, Eduardo | - |
dc.contributor.author | Castelo-Branco, Miguel | - |
dc.date.accessioned | 2023-08-28T09:55:46Z | - |
dc.date.available | 2023-08-28T09:55:46Z | - |
dc.date.issued | 2017-09-12 | - |
dc.identifier.issn | 2045-2322 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/108383 | - |
dc.description.abstract | Retinitis Pigmentosa is a group of hereditary retinal dystrophy disorders associated with progressive peripheral visual field loss. The impact of this retinal loss in cortical gray matter volume has not been addressed before in Retinitis Pigmentosa patients with low vision. Voxel-based morphometry was applied to study whole brain gray matter volume changes in 27 Retinitis Pigmentosa patients with partially preserved vision and 38 age- and gender-matched normally sighted controls to determine whether peripheral visual loss can lead to changes in gray matter volume. We found significant reductions in gray matter volume that were restricted to the occipital cortex of patients. The anteromedial pattern of reduced gray matter volume in visual primary and association cortices was significantly correlated with the extent of the peripheral visual field deficit in this cohort. Moreover, this pattern was found to be associated with the extent of visual field loss. In summary, we found specific visual cortical gray matter loss in Retinitis Pigmentosa patients associated with their visual function profile. The spatial pattern of gray matter loss is consistent with disuse-driven neuronal atrophy which may have clinical implications for disease management, including prosthetic restoration strategies. | pt |
dc.language.iso | eng | pt |
dc.publisher | Springer Nature | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject.mesh | Adult | pt |
dc.subject.mesh | Aged | pt |
dc.subject.mesh | Female | pt |
dc.subject.mesh | Gray Matter | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Magnetic Resonance Imaging | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Middle Aged | pt |
dc.subject.mesh | Organ Size | pt |
dc.subject.mesh | Retina | pt |
dc.subject.mesh | Retinitis Pigmentosa | pt |
dc.subject.mesh | Vision Tests | pt |
dc.subject.mesh | Vision, Low | pt |
dc.subject.mesh | Visual Acuity | pt |
dc.subject.mesh | Visual Field Tests | pt |
dc.subject.mesh | Visual Fields | pt |
dc.subject.mesh | Young Adult | pt |
dc.title | Structure-function correlations in Retinitis Pigmentosa patients with partially preserved vision: a voxel-based morphometry study | pt |
dc.type | article | - |
degois.publication.firstPage | 11411 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Scientific Reports | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1038/s41598-017-11317-7 | pt |
degois.publication.volume | 7 | pt |
dc.date.embargo | 2017-09-12 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | CIBIT - Coimbra Institute for Biomedical Imaging and Translational Research | - |
crisitem.author.researchunit | CEMMPRE - Centre for Mechanical Engineering, Materials and Processes | - |
crisitem.author.researchunit | CIBIT - Coimbra Institute for Biomedical Imaging and Translational Research | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CIBIT - Coimbra Institute for Biomedical Imaging and Translational Research | - |
crisitem.author.orcid | 0000-0003-4418-2638 | - |
crisitem.author.orcid | 0000-0002-1020-4758 | - |
crisitem.author.orcid | 0000-0002-1387-9953 | - |
crisitem.author.orcid | 0000-0002-2739-9854 | - |
crisitem.author.orcid | 0000-0003-4364-6373 | - |
Appears in Collections: | I&D ICNAS - Artigos em Revistas Internacionais I&D IBILI - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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Digestive-and-appendicular-softparts-with-behavioural-implications-in-a-large-Ordovician-trilobite-from-the-Fezouata-Lagersttte-MoroccoScientific-Reports.pdf | 7.82 MB | Adobe PDF | View/Open |
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