Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/108297
Title: | Recent Advances and Challenges of mTOR Inhibitors Use in the Treatment of Patients with Tuberous Sclerosis Complex | Authors: | Palavra, Filipe Robalo, Conceição Reis, Flávio |
Issue Date: | 2017 | Publisher: | Hindawi | Project: | Pest- C/SAU/UI3282/2013 UID/NEU/04539/2013 FEDER-COMPETE (FCOMP-01-0124-FEDER-028417 and POCI-01-0145-FEDER-007440) |
Serial title, monograph or event: | Oxidative Medicine and Cellular Longevity | Volume: | 2017 | Abstract: | Tuberous sclerosis complex (TSC) is a genetic condition characterized by the presence of benign, noninvasive, and tumor-like lesions called hamartomas that can affect multiple organ systems and are responsible for the clinical features of the disease. In the majority of cases, TSC results from mutations in the TSC1 and TSC2 genes, leading to the overactivation of the mammalian target of rapamycin (mTOR) signalling pathway, which controls several cell functions, including cell growth, proliferation, and survival. The establishment of a connection between TSC and mTOR led to the clinical use of drugs known as mTOR inhibitors (like rapamycin, also known as sirolimus and everolimus), which are becoming an increasingly interesting tool in the management of TSC-associated features, such as subependymal giant cell astrocytomas, renal angiomyolipomas, and also epilepsy. However, the intrinsic characteristics of these drugs and their systemic effects in such a heterogeneous condition pose many challenges in clinical practice, so that some questions remain unanswered. This article provides an overview of the pharmacological aspects of mTOR inhibitors about the clinical trials leading to their approval in TSC-related conditions and exposes current challenges and future directions associated with this promising therapeutic line. | URI: | https://hdl.handle.net/10316/108297 | ISSN: | 1942-0900 1942-0994 |
DOI: | 10.1155/2017/9820181 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Recent-Advances-and-Challenges-of-mTOR-Inhibitors-Use-in-the-Treatment-of-Patients-with-Tuberous-Sclerosis-ComplexOxidative-Medicine-and-Cellular-Longevity.pdf | 1.54 MB | Adobe PDF | View/Open |
Page view(s)
50
checked on Aug 14, 2024
Download(s)
24
checked on Aug 14, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License