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https://hdl.handle.net/10316/108284
Title: | Restoring heart function and electrical integrity: closing the circuit | Authors: | Monteiro, Luís Miguel Vasques-Nóvoa, Francisco Ferreira, Lino Pinto-do-Ó, Perpétua Nascimento, Diana Santos |
Issue Date: | 2017 | Publisher: | Springer Nature | Project: | Programa MIT-Fundação para Ciência e Tecnologia (FCT) under the project “CARDIOSTEM-Engineered cardiac tissues and stem cell-based therapies for cardiovascular applications” (MITP-TB/ECE/0013/2013) | Serial title, monograph or event: | npj Regenerative Medicine | Volume: | 2 | Issue: | 1 | Abstract: | Cardiovascular diseases are the main cause of death in the world and are often associated with the occurrence of arrhythmias due to disruption of myocardial electrical integrity. Pathologies involving dysfunction of the specialized cardiac excitatory/conductive tissue are also common and constitute an added source of morbidity and mortality since current standard therapies withstand a great number of limitations. As electrical integrity is essential for a well-functioning heart, innovative strategies have been bioengineered to improve heart conduction and/or promote myocardial repair, based on: (1) gene and/or cell delivery; or (2) conductive biomaterials as tools for cardiac tissue engineering. Herein we aim to review the state-of-art in the area, while briefly describing the biological principles underlying the heart electrical/conduction system and how this system can be disrupted in heart disease. Suggestions regarding targets for future studies are also presented. | URI: | https://hdl.handle.net/10316/108284 | ISSN: | 2057-3995 | DOI: | 10.1038/s41536-017-0015-2 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
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