Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/107612
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rodrigues-Santos, Paulo | - |
dc.contributor.author | López-Sejas, Nelson | - |
dc.contributor.author | Almeida, Jani-Sofia | - |
dc.contributor.author | Ruzičková, Lenka | - |
dc.contributor.author | Couceiro, Patrícia | - |
dc.contributor.author | Alves, Vera | - |
dc.contributor.author | Campos, Carmen | - |
dc.contributor.author | Alonso, Corona | - |
dc.contributor.author | Tarazona, Raquel | - |
dc.contributor.author | Freitas-Tavares, Paulo | - |
dc.contributor.author | Solana, Rafael | - |
dc.contributor.author | Santos-Rosa, Manuel | - |
dc.date.accessioned | 2023-07-24T09:50:57Z | - |
dc.date.available | 2023-07-24T09:50:57Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1664-3224 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/107612 | - |
dc.description.abstract | Natural killer (NK) cells are a very important component of the innate immune response involved in the lysis of virus infected and tumor cells. Aging has a profound impact in the frequency, phenotype and function of NK cells. Chronic Myeloid Leukemia (CML) is caused by the BCR-ABL gene formation encoding aberrant oncoprotein tyrosine kinase. Treatment with tyrosine kinase inhibitors (TKIs) induces durable deep molecular response. The response to treatment and life expectancy is lower in older patients with chronic phase of CML than in younger patients. In this work we analyse NK cells from TKI-treated CML patients and healthy controls stratified according to age. We have analyzed the expression of NK receptors, activation markers, NK cell differentiation in CD56bright and CD56dim NK cell subsets and the expression of CD107a and IFN-γ in NK cells stimulated with K562. Whereas significant differences on the phenotype and function of NK cells were found between middle-aged (35-65 years old) and elderly (older than 65) healthy individuals, NK cells from TKI-treated CML patients do not show significant differences related with age in most parameters studied, indicating that age is not a limitation of the NK cell recovery after treatment with TKI. Our results also revealed differences in the expression of NK receptors, activation markers and functional assays in NK cells from TKI-treated CML patients compared with age-matched healthy controls. These results highlight the relevance of NK cells in TKI-treated patients and the need of an extensive analysis of the effect of aging on NK cell phenotype and function in these patients in order to define new NK-cell based strategies directed to control CML progression and achieve long-term disease remission after TKI cessation. | pt |
dc.language.iso | eng | pt |
dc.publisher | Frontiers Media S.A. | pt |
dc.relation | POCI-01-0145-FEDER-007440 | pt |
dc.relation | program Iberoamerica Scholarships. Santander Research Santander Universities 2016–2017 | pt |
dc.relation | grants PI13/02691 and PI16/01615 (to RS and CA) from Spanish Ministry ofHealth | pt |
dc.relation | SAF2017-87538-R (to RT) from the Ministry of Economy and Competitiveness of Spain | pt |
dc.relation | IB16164 and GR18085 from Junta de Extremadura | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | aging | pt |
dc.subject | CML | pt |
dc.subject | NK receptors | pt |
dc.subject | activation markers | pt |
dc.subject | differentiation markers | pt |
dc.subject | cytokines | pt |
dc.subject | NK cell subsets | pt |
dc.subject | tyrosine kinase inhibitors | pt |
dc.subject.mesh | Adult | pt |
dc.subject.mesh | Aged | pt |
dc.subject.mesh | Aged, 80 and over | pt |
dc.subject.mesh | Aging | pt |
dc.subject.mesh | Antineoplastic Agents | pt |
dc.subject.mesh | Cell Differentiation | pt |
dc.subject.mesh | Female | pt |
dc.subject.mesh | Genes, abl | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | K562 Cells | pt |
dc.subject.mesh | Killer Cells, Natural | pt |
dc.subject.mesh | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | pt |
dc.subject.mesh | Lymphocyte Activation | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Middle Aged | pt |
dc.subject.mesh | Protein Kinase Inhibitors | pt |
dc.subject.mesh | Treatment Outcome | pt |
dc.subject.mesh | Age Factors | pt |
dc.title | Effect of Age on NK Cell Compartment in Chronic Myeloid Leukemia Patients Treated With Tyrosine Kinase Inhibitors | pt |
dc.type | article | - |
degois.publication.firstPage | 2587 | pt |
degois.publication.title | Frontiers in Immunology | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3389/fimmu.2018.02587 | pt |
degois.publication.volume | 9 | pt |
dc.date.embargo | 2018-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.orcid | 0000-0002-7185-9336 | - |
crisitem.author.orcid | 0000-0001-7832-4134 | - |
crisitem.author.orcid | 0000-0003-0789-8637 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Effect of Age on NK Cell Compartment in Chronic Myeloid Leukemia Patients Treated With Tyrosine Kinase Inhibitors.pdf | 2.44 MB | Adobe PDF | View/Open |
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