Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/107595
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Campos, António | - |
dc.contributor.author | Campos, Elisa J. | - |
dc.contributor.author | Carmo, Anália do | - |
dc.contributor.author | Caramelo, Francisco | - |
dc.contributor.author | Martins, João | - |
dc.contributor.author | Sousa, João P. | - |
dc.contributor.author | Ambrósio, António | - |
dc.contributor.author | Silva, Rufino | - |
dc.date.accessioned | 2023-07-21T10:05:40Z | - |
dc.date.available | 2023-07-21T10:05:40Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 2326-0254 | - |
dc.identifier.uri | https://hdl.handle.net/10316/107595 | - |
dc.description.abstract | Objective: To evaluate short-term markers of outcome in diabetic macular edema (DME). Methods: Prospective interventional case series included 122 eyes of 122 patients with recently diagnosed DME. Eyes were treated with a 3-monthly loading dose of ranibizumab or aflibercept and pro re nata thereafter. Serial enhanced deep imaging SD-OCT high resolution scans were used to measure subfoveal choroidal thickness (SFCT) and central retinal thickness (CRT). Anatomic (10% CRT decrease) and functional responses (best corrected visual acuity, BCVA gain ≥5 letters) were assessed at 3 months and 6 months using univariate and multivariate analyses. Parameters tested were gender, duration of diabetes, HbA1c, hypertension, CRT, SFCT, BCVA, ellipsoid zone (EZ) status, subfoveal neuroretinal detachment (SND), anti-VEGF used and laser naivety. A logistic regression model was applied to find independent markers outcome. Results: BCVA increased, CRT and SFCT decreased at 3 months and 6 months. Good metabolic control (p = 0.003), intact baseline EZ (p = 0.030), EZ re-grading at 3 M (p < 0.001) and laser naivety (p = 0.001) were associated with better functional outcome. The multivariate linear regression model showed that baseline SND and CRT are predictors of anatomic response, while lower baseline BCVA and intact EZ are predictors of functional response. Conclusion: The presence of SND predicts anatomic response only, while an intact EZ is critical to achieve a good functional outcome in DME. | pt |
dc.language.iso | eng | pt |
dc.publisher | Springer Nature | pt |
dc.relation | UID/NEU/04539/2013 | pt |
dc.relation | POCI-01-0145-FEDER- 007440 | pt |
dc.relation | FCT Postdoctoral Fellowship SFRH/BPD/93672/2013 | pt |
dc.relation | Novartis | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Diabetic macular edema | pt |
dc.subject | Outcome factors | pt |
dc.subject | Spectral-domain optical coherence tomography | pt |
dc.subject | Antivascular endothelial growth factor | pt |
dc.subject | Laser | pt |
dc.title | Evaluation of markers of outcome in real-world treatment of diabetic macular edema | pt |
dc.type | article | pt |
degois.publication.firstPage | 27 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Eye and Vision | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1186/s40662-018-0119-9 | - |
degois.publication.volume | 5 | pt |
dc.date.embargo | 2018-01-01 | * |
dc.identifier.pmid | 30386806 | - |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.orcid | 0000-0003-0490-5889 | - |
crisitem.author.orcid | 0000-0002-7704-4736 | - |
crisitem.author.orcid | 0000-0002-0015-8604 | - |
crisitem.author.orcid | 0000-0002-0477-1641 | - |
crisitem.author.orcid | 0000-0001-8676-0833 | - |
Appears in Collections: | I&D IBILI - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Evaluation of markers of outcome in real-world treatment of diabetic macular edema.pdf | 1.76 MB | Adobe PDF | View/Open |
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