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Título: | Synthetic Calcium Phosphate Ceramics as a Potential Treatment for Bisphosphonate-Related Osteonecrosis of the Jaw | Autor: | Paulo, Siri Laranjo, Mafalda Abrantes, Ana M. Casalta-Lopes, João Santos, Kathleen Gonçalves, Ana C. Paula, Anabela Baptista Marto, Carlos Miguel Ribeiro, Ana Bela Sarmento Carrilho, Eunice Serra, Arménio C. Botelho, Maria F. Ferreira, Manuel M. |
Palavras-chave: | biomaterials; biomineralization; bisphosphonate-related osteonecrosis of the jaw; cellular biology; gingival fibroblasts; osteonecrosis; zoledronate | Data: | 6-Jun-2019 | Editora: | MDPI | Projeto: | FCT, COMPETE-FEDER (Strategic Project PEst-C/SAU/UI3282/2013 and UID/NEU/04539/2013) | Título da revista, periódico, livro ou evento: | Materials | Volume: | 12 | Número: | 11 | Resumo: | (1) Background: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is one of the most often seen side effects in patients treated with nitrogen-containing bisphosphonates (BPs), a post-surgical non-healing wound condition. Since calcium phosphate (CP) compounds are able to adsorb zoledronate (ZOL) when used as a drug delivery vehicle, we aimed to verify if these ceramics might have a potential protective effect for soft tissues surrounding surgical osseous wounds. (2) Methods: The chemical reaction between ZOL and CP compounds was evaluated through ultraviolet-visible spectroscopy and elemental analysis. A primary culture of human gingival fibroblasts (HGF) was established as a model to evaluate the cytotoxicity of the association of ZOL (5-500 μM) and of ZOL/biphasic calcium phosphates (BCP). Metabolic activity, cell viability, types of cell death, the cell cycle through, and the migration ability of human gingival fibroblasts were evaluated. (3) Results: ZOL was adsorbed by biphasic calcium phosphate compounds in an aqueous solution. The HGF were sensitive to ZOL toxicity; nevertheless, ZOL/BCP showed a significant protective effect regarding metabolic activity, cell viability, and cell migration. (4) Conclusions: BCP interaction with ZOL reduces or abolishes its toxicity in HGF. This finding represents a potential solution for BRONJ in the case of patients undergoing therapy with ZOL. | URI: | https://hdl.handle.net/10316/107149 | ISSN: | 1996-1944 | DOI: | 10.3390/ma12111840 | Direitos: | openAccess |
Aparece nas coleções: | I&D IBILI - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais |
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Synthetic-calcium-phosphate-ceramics-as-a-potential-treatment-for-bisphosphonaterelated-osteonecrosis-of-the-jawMaterials.pdf | 2.72 MB | Adobe PDF | Ver/Abrir |
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