Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/106997
Title: | Neuroendocrine Carcinoma and Intracystic Papillary Neoplasm: A Rare Association in the Gallbladder | Authors: | Fraga, João Caetano Oliveira, Rui Alexandrino, Henrique Cipriano, Maria Augusta |
Keywords: | Neuroendrocine carcinoma; Gallbladder; Intracystic papillary neoplasm; Carcinoma neuroendocrine; Vesícula biliar; Neoplasia papilar intraquística | Issue Date: | Aug-2019 | Publisher: | Karger | Serial title, monograph or event: | GE Portuguese Journal of Gastroenterology | Volume: | 26 | Issue: | 5 | Abstract: | Neuroendocrine carcinoma of the gallbladder is a very rare neoplasia comprising only 0.2% of all the gastrointestinal neuroendocrine tumors. We present the case of an 85-year-old male with nonspecific gastrointestinal symptoms, progressive weight loss, and deterioration in the preceding 15 days. Imaging study showed a 5-cm polypoid mass localized at the gallbladder fundus, leading to a radical cholecystectomy. Pathology revealed the known lobulated polypoid lesion, on cut section, constituted by friable tissue without evident infiltration of the gallbladder wall and a contiguous friable, brown, flat lesion. Histological evaluation displayed a small cell neuroendocrine carcinoma, consisting of intermediate and small cells, rounded or spindle, with extensive areas of necrosis, with positivity for neuroendocrine immunomarkers, associated with intracystic papillary neoplasm with high and low dysplasia. This is an uncommon association with few cases presented in the literature. Carcinoma neuroendócrino da vesícula biliar é uma neoplasia muito rara, compreendendo cerca de 0.2% de todas as neoplasias neuroendócrinas do trato gastrointestinal. Apresentamos um caso de um homem de 85 anos, com sintomas gastrointestinais inespecíficos, perda de peso progressiva e deterioração do estado geral com 15 dias de evolução. Estudos de imagem demonstraram lesão polipóide com 5 cm localizada no fundo da vesícula biliar, motivando colecistectomia. Macroscopicamente observou-se lesão polipoide composta por tecido acastanhado e friável. Estudo histológico demonstrou lesão constituída por pequenas células, com extensas áreas de necrose e positivas para marcadores neuroendócrinos, associada a neoplasia papilar intraquística com displasia de baixo e alto grau. Esta associação é incomum, com apenas raros casos descritos na literatura. |
URI: | https://hdl.handle.net/10316/106997 | ISSN: | 2341-4545 | DOI: | 10.1159/000495523 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Neuroendocrine Carcinoma and Intracystic Papillary Neoplasm A Rare Association in the Gallbladder.pdf | 1.78 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
3
checked on Oct 14, 2024
WEB OF SCIENCETM
Citations
4
checked on Oct 2, 2024
Page view(s)
60
checked on Oct 15, 2024
Download(s)
28
checked on Oct 15, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License