Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/106873
Title: Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer properties
Authors: Matos, Cristina P
Adiguzel, Zelal
Yildizhan, Yasemin
Cevatemre, Buse
Bagci-Onder, Tugba
Cevik, Ozge
Nunes, Patrique
Ferreira, Liliana P. 
Carvalho, Maria Deus
Campos, Débora L
Pavan, Fernando R
Pessoa, João Costa 
Garcia, Maria Helena
Tomaz, Ana Isabel
Correia, Isabel
Acilan, Ceyda
Keywords: Fe(III) complexes; Phenanthroline; Anticancer; Cytotoxicity; Genotoxicity
Issue Date: Dec-2019
Publisher: Elsevier
Project: This work was supported by Fundaç~ao para a Ci^encia e a Tecnologia (FCT) (projects UID/QUI/00100/ 2013, UID/MULTI/04349/2013, UID/BIO/04565/2013, RECI/QEQ-QIN/0189/2012, RECI/QEQ-MED/0330/ 2012, IF/01179/2013), Programa Operacional Regional de Lisboa (LISBOA-01-0145-FEDER-007317) and programme Investigador FCT (FSE, POPH). The Portuguese NMR and Mass Spectrometry ISTeUL Centers are acknowledged for the access to the equipment. The authors thank Fernanda Marques for a preliminary cytotoxicity assessment of the compounds and also Ali Cenk Aksu for calculating the IC50 values. This work was supported by Koç University School of Medicine (KUSOM) and the authors gratefully acknowledge use of the services and facilities of the Koç University Research Center for Translational Medicine (KUTTAM), funded by the Republic of Turkey Ministry of Development. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Ministry of Development. 
Serial title, monograph or event: Data in Brief
Volume: 27
Abstract: This dataset is related to the research article entitled "May iron(III) complexes containing phenanthroline derivatives as ligands be prospective anticancer agents?" [1]. It includes the characterization by UV-Vis absorption spectroscopy and magnetic techniques of a group of mixed ligand Fe(III) complexes bearing a tripodal aminophenolate ligand L2-, H2L = N,N-bis(2-hydroxy-3,5-dimethylbenzyl)-N-(2-pyridylmethyl)amine, and different aromatic bases (NN = 2,2'-bipyridine [Fe(L)(bipy)]PF6 (1), 1,10-phenanthroline [Fe(L)(phen)]PF6 (2), or a phenanthroline derivative co-ligand: [Fe(L)(amphen)]NO3 (3), [Fe(L)(amphen)]PF6 (3a), [Fe(L)(Clphen)]PF6 (4), [Fe(L)(epoxyphen)]PF6 (5) (where amphen = 1,10-phenanthroline-5-amine, epoxyphen = 5,6-epoxy-5,6-dihydro-1,10-phenanthroline, Clphen = 5-chloro-1,10-phenanthroline), as well as [Fe(L)(EtOH)]NO3 (6), [Fe(phen)Cl3] (7) and [Fe(amphen)Cl3] (8). Data on their hydrolytic stability in physiological buffers is shown, as well as on their interaction with calf thymus DNA by spectroscopic tools. Additionally, the anticancer efficacy and the cellular death mechanisms activated in response to these drugs in HeLa, H1299 and MDA-MB-231 cells are provided.
URI: https://hdl.handle.net/10316/106873
ISSN: 23523409
DOI: 10.1016/j.dib.2019.104548
Rights: openAccess
Appears in Collections:FCTUC Física - Artigos em Revistas Internacionais

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