Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/106505
DC Field | Value | Language |
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dc.contributor.author | Llorens, Franc | - |
dc.contributor.author | Hermann, Peter | - |
dc.contributor.author | Villar-Piqué, Anna | - |
dc.contributor.author | Diaz-Lucena, Daniela | - |
dc.contributor.author | Nägga, Katarina | - |
dc.contributor.author | Hansson, Oskar | - |
dc.contributor.author | Santana, Isabel | - |
dc.contributor.author | Schmitz, Matthias | - |
dc.contributor.author | Schmidt, Christian | - |
dc.contributor.author | Varges, Daniela | - |
dc.contributor.author | Goebel, Stefan | - |
dc.contributor.author | Dumurgier, Julien | - |
dc.contributor.author | Zetterberg, Henrik | - |
dc.contributor.author | Blennow, Kaj | - |
dc.contributor.author | Paquet, Claire | - |
dc.contributor.author | Baldeiras, Inês | - |
dc.contributor.author | Ferrer, Isidro | - |
dc.contributor.author | Zerr, Inga | - |
dc.date.accessioned | 2023-04-05T11:58:50Z | - |
dc.date.available | 2023-04-05T11:58:50Z | - |
dc.date.issued | 2020-01-30 | - |
dc.identifier.issn | 2041-1723 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/106505 | - |
dc.description.abstract | The clinical diagnosis of vascular dementia (VaD) is based on imaging criteria, and specific biochemical markers are not available. Here, we investigated the potential of cerebrospinal fluid (CSF) lipocalin 2 (LCN2), a secreted glycoprotein that has been suggested as mediating neuronal damage in vascular brain injuries. The study included four independent cohorts with a total n = 472 samples. LCN2 was significantly elevated in VaD compared to controls, Alzheimer's disease (AD), other neurodegenerative dementias, and cognitively unimpaired patients with cerebrovascular disease. LCN2 discriminated VaD from AD without coexisting VaD with high accuracy. The main findings were consistent over all cohorts. Neuropathology disclosed a high percentage of macrophages linked to subacute infarcts, reactive astrocytes, and damaged blood vessels in multi-infarct dementia when compared to AD. We conclude that CSF LCN2 is a promising candidate biochemical marker in the differential diagnosis of VaD and neurodegenerative dementias. | pt |
dc.description.sponsorship | This study was funded by the ADDF (Alzheimer’s Drug Discovery Foundation—Grant 201810- 2017419) to F.L. and I.Z., the Instituto Carlos III (grants CP16/00041 and PI19/00144) to F.L., the Robert Koch Institute through funds from the German Federal Ministry of Health (grant no. 1369–341) to I.Z., and the Spanish Ministry of Health, Instituto Carlos III (Fondo de Investigación Sanitaria—FIS PI14/00757) to I.F. H.Z. is a Wallenberg Academy Fellow supported by grants from the Swedish Research Council, the European Research Council, Swedish State Support for Clinical Research (ALFGBG), and the UK Dementia Research Institute at UCL. K.B. holds the Torsten Söderberg Professorship of Medicine and is supported by grants from the Swedish Research Council, the Swedish Brain Foundation, the Swedish Alzheimer Foundation, and Swedish State Support for Clinical Research (ALFGBG). | - |
dc.language.iso | eng | pt |
dc.publisher | Springer Nature | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject.mesh | Aged | pt |
dc.subject.mesh | Aged, 80 and over | pt |
dc.subject.mesh | Alzheimer Disease | pt |
dc.subject.mesh | Biomarkers | pt |
dc.subject.mesh | Cerebrovascular Disorders | pt |
dc.subject.mesh | Dementia, Vascular | pt |
dc.subject.mesh | Diagnosis, Differential | pt |
dc.subject.mesh | Female | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Lipocalin-2 | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Middle Aged | pt |
dc.title | Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia | pt |
dc.type | article | - |
degois.publication.firstPage | 619 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Nature Communications | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1038/s41467-020-14373-2 | pt |
degois.publication.volume | 11 | pt |
dc.date.embargo | 2020-01-30 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-8114-9434 | - |
crisitem.author.orcid | 0000-0002-8106-7308 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Cerebrospinal-fluid-lipocalin-2-as-a-novel-biomarker-for-the-differential-diagnosis-of-vascular-dementiaNature-Communications.pdf | 3.08 MB | Adobe PDF | View/Open |
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