Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/106372
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Paulo, Siri | - |
dc.contributor.author | Laranjo, Mafalda | - |
dc.contributor.author | Paula, Anabela | - |
dc.contributor.author | Abrantes, Ana Margarida | - |
dc.contributor.author | Martins, João | - |
dc.contributor.author | Marto, Carlos Miguel | - |
dc.contributor.author | Coelho, Ana Sofia | - |
dc.contributor.author | Casalta-Lopes, João | - |
dc.contributor.author | Carvalho, Lina | - |
dc.contributor.author | Carrilho, Eunice | - |
dc.contributor.author | Serra, Arménio | - |
dc.contributor.author | Botelho, Maria Filomena | - |
dc.contributor.author | Ferreira, Manuel Marques | - |
dc.date.accessioned | 2023-03-31T11:36:46Z | - |
dc.date.available | 2023-03-31T11:36:46Z | - |
dc.date.issued | 2020-04-22 | - |
dc.identifier.issn | 1996-1944 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/106372 | - |
dc.description.abstract | Bisphosphonate-associated osteonecrosis of the jaw (BRONJ), a post-surgical non-healing wound condition, is one of the most common side effects in patients treated with nitrogen-containing bisphosphonates. Its physiopathology has been related with suppression of bone turnover, of soft tissue healing and infection. Biphasic calcium phosphates (BCP) are used as a drug delivery vehicle and as a bone substitute in surgical wounds. Due to their capacity to adsorb zoledronate, it was hypothesized these compounds might have a protective effect on the soft tissues in BRONJ wounds. To address this hypothesis, a reproducible in vivo model of BRONJ in Wistar rats was used. This model directly relates chronic bisphosphonate administration with the development of osteonecrosis of the jaw after tooth extraction. BCP granules were placed in the alveolus immediately after tooth extraction in the test group. The animals were evaluated through nuclear medicine, radiology, macroscopic observation, and histologic analysis. Encouragingly, calcium phosphate ceramics were able to limit zoledronate toxicity in vivo and to favor healing, which was evidenced by medical imaging (nuclear medicine and radiology), macroscopically, and through histology. The studied therapeutic option presented itself as a potential solution to prevent the development of maxillary osteonecrosis. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | PEst-C/SAU/UI3282/2013 | pt |
dc.relation | UID/NEU/04539/2013 | pt |
dc.relation | UID/NEU/04539/2019 | pt |
dc.relation | UIDB/04539/2020 | pt |
dc.relation | UIDP/04539/2020 | pt |
dc.relation | POCI-01-0145-FEDER-007440 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | animal models | pt |
dc.subject | bisphosphonate-related osteonecrosis of the jaw (BRONJ) | pt |
dc.subject | biphasic calcium phosphates (BCP) | pt |
dc.subject | zoledronate | pt |
dc.title | Calcium Phosphate Ceramics Can Prevent Bisphosphonate-Related Osteonecrosis of the Jaw | pt |
dc.type | article | - |
degois.publication.firstPage | 1955 | pt |
degois.publication.issue | 8 | pt |
degois.publication.title | Materials | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/ma13081955 | pt |
degois.publication.volume | 13 | pt |
dc.date.embargo | 2020-04-22 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.fulltext | Com Texto completo | - |
item.cerifentitytype | Publications | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology - CIBB | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology | - |
crisitem.author.researchunit | iNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG and ITQB) | - |
crisitem.author.researchunit | CEMMPRE - Centre for Mechanical Engineering, Materials and Processes | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0003-0689-6007 | - |
crisitem.author.orcid | 0000-0003-4185-7871 | - |
crisitem.author.orcid | 0000-0001-9269-5417 | - |
crisitem.author.orcid | 0000-0002-2924-7926 | - |
crisitem.author.orcid | 0000-0001-8349-4488 | - |
crisitem.author.orcid | 0000-0002-5759-5557 | - |
crisitem.author.orcid | 0000-0001-8664-2757 | - |
crisitem.author.orcid | 0000-0001-7202-1650 | - |
crisitem.author.orcid | 0000-0002-5968-6161 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais FCTUC Eng.Química - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Calcium-phosphate-ceramics-can-prevent-bisphosphonaterelated-osteonecrosis-of-the-jawMaterials.pdf | 1.66 MB | Adobe PDF | View/Open |
WEB OF SCIENCETM
Citations
4
checked on May 2, 2023
Page view(s)
129
checked on Aug 28, 2024
Download(s)
31
checked on Aug 28, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License