Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/106219
DC Field | Value | Language |
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dc.contributor.author | Gouveia, Marcos | - |
dc.contributor.author | Zemljič-Jokhadar, Špela | - |
dc.contributor.author | Vidak, Marko | - |
dc.contributor.author | Stojkovič, Biljana | - |
dc.contributor.author | Derganc, Jure | - |
dc.contributor.author | Travasso, Rui D.M. | - |
dc.contributor.author | Liovic, Mirjana | - |
dc.date.accessioned | 2023-03-27T08:37:21Z | - |
dc.date.available | 2023-03-27T08:37:21Z | - |
dc.date.issued | 2020-04-09 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://hdl.handle.net/10316/106219 | - |
dc.description.abstract | Keratins are one of the most abundant proteins in epithelial cells. They form a cytoskeletal filament network whose structural organization seriously conditions its function. Dynamic keratin particles and aggregates are often observed at the periphery of mutant keratinocytes related to the hereditary skin disorder epidermolysis bullosa simplex, which is due to mutations in keratins 5 and 14. To account for their emergence in mutant cells, we extended an existing mathematical model of keratin turnover in wild-type cells and developed a novel 2D phase-field model to predict the keratin distribution inside the cell. This model includes the turnover between soluble, particulate and filamentous keratin forms. We assumed that the mutation causes a slowdown in the assembly of an intermediate keratin phase into filaments, and demonstrated that this change is enough to account for the loss of keratin filaments in the cell's interior and the emergence of keratin particles at its periphery. The developed mathematical model is also particularly tailored to model the spatial distribution of keratins as the cell changes its shape. | pt |
dc.description.sponsorship | This work resulted from a collaboration initiated by the COST Action CA15214 (EuroCellNet). MG and RDMT thank the support of FEDER funds through the Operational Program Competitiveness Factors—COMPETE and by national funds by FCT—Foundation for Science and Technology under the strategic project UID/FIS/04564/2016 and under POCI-01-0145-FEDER-031743 –PTDC/BIA-CEL/31743/2017. MG thanks support by UE/FEDER funds through the program COMPETE 2020, under the project CENTRO-01-0145-FEDER-000014 (MATIS). The work was also supported by Slovenian Research Agency Program Grants P1-0055 and P1-0390, the CELSA Alliance grant to ML, and Republic of Slovenia Ministry of Education, Science and Sport and the EraCoSysMed (JTC-2 2017) “4D-HEALING” grant. | - |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | keratin | pt |
dc.subject | epidermolysis bullosa simplex | pt |
dc.subject | mutation | pt |
dc.subject | phase-field model | pt |
dc.subject | reaction-diffusionadvection equation | pt |
dc.title | Keratin Dynamics and Spatial Distribution in Wild-Type and K14 R125P Mutant Cells-A Computational Model | pt |
dc.type | article | pt |
degois.publication.firstPage | 2596 | pt |
degois.publication.issue | 7 | pt |
degois.publication.title | International Journal of Molecular Sciences | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/ijms21072596 | - |
degois.publication.volume | 21 | pt |
dc.date.embargo | 2020-04-09 | * |
dc.identifier.pmid | 32283594 | - |
uc.date.periodoEmbargo | 0 | pt |
dc.identifier.eissn | 1422-0067 | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.orcid | 0000-0001-6078-0721 | - |
Appears in Collections: | I&D CFis - Artigos em Revistas Internacionais |
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Keratin-dynamics-and-spatial-distribution-in-wildtype-and-K14-R125P-mutant-cellsA-computational-modelInternational-Journal-of-Molecular-Sciences.pdf | 2.51 MB | Adobe PDF | View/Open |
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