Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/106174
Title: Timing of Spheno-Occipital Synchondrosis Ossification in Children and Adolescents with Cleft Lip and Palate: A Retrospective Case-Control Study
Authors: Vale, Francisco 
Francisco, Inês 
Lucas, António 
Roseiro, Ana 
Caramelo, Francisco 
Sobral, Adriana 
Keywords: cleft lip; cleft palate; cone beam computed tomography
Issue Date: 29-Nov-2020
Serial title, monograph or event: International Journal of Environmental Research and Public Health
Volume: 17
Issue: 23
Abstract: Background: Cleft lip and palate (CLP) can a ect the development of the maxilla; which may create a midfacial deficiency as well as an interference of the facial growth pattern and dentofacial esthetics. Objective: This study aimed to estimate the chronological age of complete fusion of the spheno-occipital synchondrosis (SOS) in cleft lip and palate patients and a control group; using cone beam computed tomography (CBCT) images. Methods: In this retrospective study; 125 patients were enrolled (cleft lip and palate group (n = 91); control group (n = 34)). Age comparison was made with a chi-square test; and a Kaplan–Meier analysis determined the median time to reach complete fusion of the spheno-occipital synchondrosis (p < 0.05). Results: The experimental group showed statistically significant di erences in the median time for complete ossification between males and females (p = 0.019). The median time for complete ossification of the spheno-occipital synchondrosis was; for males; 15.0 years in both groups; for females; it was 14.0 years and 13.0 years in the experimental group and in the control group; respectively. Both for males and females; there were no statistically significant di erences between experimental and control groups (p = 0.104). Conclusions: The present study showed no di erences in the ossification of the spheno-occipital synchondrosis between individuals with and without cleft lip and/or palate.
URI: https://hdl.handle.net/10316/106174
ISSN: 1660-4601
DOI: 10.3390/ijerph17238889
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
I&D ICBR - Artigos em Revistas Internacionais

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