Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/105823
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Delgado-García, Mercedes | - |
dc.contributor.author | Weynand, Birgit | - |
dc.contributor.author | Gómez-Izquierdo, Lourdes | - |
dc.contributor.author | Hernández, María José | - |
dc.contributor.author | Blanco, Ángela María | - |
dc.contributor.author | Varela, Mar | - |
dc.contributor.author | Matias-Guiu, Xavier | - |
dc.contributor.author | Nadal, Ernest | - |
dc.contributor.author | Márquez-Lobo, Bélgica | - |
dc.contributor.author | Alarcão, Ana | - |
dc.contributor.author | de Álava, Enrique | - |
dc.contributor.author | Biscuola, Michele | - |
dc.date.accessioned | 2023-03-09T12:14:34Z | - |
dc.date.available | 2023-03-09T12:14:34Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1471-2407 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/105823 | - |
dc.description.abstract | Background: Detection of epidermal growth factor receptor (EGFR) mutations in exons 18–21 is recommended in all patients with advanced Non-small-cell lung carcinoma due to the demonstrated efficiency of the standard therapy with tyrosine kinase inhibitors in EGFR-mutated patients. Therefore, choosing a suitable technique to test EGFR mutational status is crucial to warrant a valid result in a short turnaround time using the lowest possible amount of tissue material. The Idylla™ EGFR Mutation Test is a simple, fast and reliable method designed for the detection of EGFR mutations from formalin-fixed paraffin-embedded samples. The aim of this study was the Clinical Performace Evaluation of the Idylla™ EGFR Mutation Test on the Idylla™ System. Methods: EGFR mutational status was determined on 132 archived formalin-fixed paraffin-embedded tissue sections with Idylla™ technology. Results were compared with the results previously obtained by routine method in the reference lab (Therascreen® EGFR RGQ PCR v2, Qiagen in Molecular Pathology lab, Hospital Universitario Virgen del Rocío de Sevilla). Results: The overall agreement between results obtained with the Idylla™ EGFR Mutation Test and the Comparator test method was 95.38% (with 1-sided 95% lower limit of 91.7%) showing Positive Diagnostic Agreement of 93.22% and Negative Diagnostic Agreement of 97.18%, with a Limit Of Detection ≤5%. Conclusions: The Idylla™ EGFR Mutation Test passed its clinical validity performance characteristics for accuracy. | pt |
dc.language.iso | eng | pt |
dc.publisher | Springer Nature | pt |
dc.relation | Supported by each clinical center. Biocartis provided free-of-charge Idylla™ EGFR Mutation Test cartridges. | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Non-small-cell lung carcinoma | pt |
dc.subject | EGFR | pt |
dc.subject | Mutations | pt |
dc.title | Clinical performance evaluation of the Idylla™ EGFR Mutation Test on formalin-fixed paraffin-embedded tissue of non-small cell lung cancer | pt |
dc.type | article | - |
degois.publication.firstPage | 275 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | BMC Cancer | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1186/s12885-020-6697-7 | pt |
degois.publication.volume | 20 | pt |
dc.date.embargo | 2020-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairetype | article | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Clinical-performance-evaluation-of-the-Idylla-EGFR-Mutation-Test-on-formalinfixed-paraffinembedded-tissue-of-nonsmall-cell-lung-cancerBMC-Cancer.pdf | 716.19 kB | Adobe PDF | Ver/Abrir |
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