Please use this identifier to cite or link to this item:
Title: Oral Bioavailability of Insulin Contained in Polysaccharide Nanoparticles
Authors: Sarmento, Bruno 
Ribeiro, António
Veiga, Francisco 
Ferreira, Domingos 
Neufeld, Ronald 
Issue Date: 8-Oct-2007
Publisher: American Chemical Society
Citation: Biomacromolecules. 8:10 (2007) 3054-3060
Abstract: The pharmacological activity of insulin-loaded dextran sulfate/chitosan nanoparticles was evaluated following oral dosage in diabetic rats. Nanoparticles were mucoadhesive and negatively charged with a mean size of 500 nm, suitable for uptake within the gastrointestinal tract. Insulin association efficiency was over 70% and was released in a pH-dependent manner under simulated gastrointestinal conditions. Orally delivered nanoparticles lowered basal serum glucose levels in diabetic rats around 35% with 50 and 100 IU/kg doses sustaining hypoglycemia over 24 h. Pharmacological availability was 5.6 and 3.4% for the 50 and 100 IU/kg doses, respectively, a significant increase over 1.6%, determined for oral insulin alone in solution. Confocal microscopic examinations of FITC-labeled insulin nanoparticles showed adhesion to rat intestinal epithelium, and internalization of insulin within the intestinal mucosa. Encapsulation of insulin into dextran sulfate/chitosan nanoparticles was a key factor in the improvement of the bioavailability of its oral delivery over insulin solution.
ISSN: 1525-7797
DOI: 10.1021/bm0703923
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
Oral Bioavailability of Insulin Contained in Polysaccharide Nanoparticles.pdf370.36 kBAdobe PDFView/Open
Show full item record


checked on Feb 18, 2020

Citations 1

checked on Dec 2, 2021

Page view(s) 50

checked on Nov 26, 2021

Download(s) 20

checked on Nov 26, 2021

Google ScholarTM




Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.