Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/105334
DC Field | Value | Language |
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dc.contributor.author | Jain, Sona | - |
dc.contributor.author | Santana, Wanessa | - |
dc.contributor.author | Dolabella, Silvio S. | - |
dc.contributor.author | Santos, André L. S. | - |
dc.contributor.author | Souto, Eliana B. | - |
dc.contributor.author | Severino, Patrícia | - |
dc.date.accessioned | 2023-02-17T10:40:48Z | - |
dc.date.available | 2023-02-17T10:40:48Z | - |
dc.date.issued | 2021-04-03 | - |
dc.identifier.issn | 1999-4923 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/105334 | - |
dc.description.abstract | Leishmaniasis is one of the deadliest neglected tropical diseases affecting 12-15 million people worldwide, especially in middle- and low-income countries. Rapid and accurate diagnosis of the disease is important for its adequate management and treatment. Several techniques are available for the diagnosis of leishmaniasis. Among these, parasitological and immunological tests are most widely used. However, in most cases, the utilized diagnostic techniques are not good enough, showing cross-reactivity and reduced accuracy. In recent years, many new methods have been reported with potential for improved diagnosis. This review focuses on the diagnosis of Leishmania exploring the biosensors and nanotechnology-based options for their detection. New developments including the use of nanomaterials as fluorophores, fluorescence quenchers as reducing agents and as dendrimers for signal improvement and amplification, together with the use of aptamers to replace antibodies are described. Future research opportunities to overcome the current limitations on the available diagnostic approaches are also discussed. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | Conselho Nacional de Desenvolvimento Científico e Tecnológico for the scientific grants (CNPq 301964/2019-0 Chamada 06/2019, Chamada CNPq nº 01/2019) | pt |
dc.relation | FCT/MEC - M-ERA-NET-0004/2015-PAIRED | pt |
dc.relation | UIDB/04469/2020 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | leishmaniasis | pt |
dc.subject | nanomaterials | pt |
dc.subject | immunosensors | pt |
dc.subject | genosensors | pt |
dc.subject | parasitic diseases | pt |
dc.title | Are Nanobiosensors an Improved Solution for Diagnosis of Leishmania? | pt |
dc.type | article | - |
degois.publication.firstPage | 491 | pt |
degois.publication.issue | 4 | pt |
degois.publication.title | Pharmaceutics | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/pharmaceutics13040491 | pt |
degois.publication.volume | 13 | pt |
dc.date.embargo | 2021-04-03 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
crisitem.author.orcid | 0000-0002-9737-6017 | - |
crisitem.project.grantno | Centre of Biological Engineering of the University of Minho | - |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Are-nanobiosensors-an-improved-solution-for-diagnosis-of-leishmaniaPharmaceutics.pdf | 2.97 MB | Adobe PDF | View/Open |
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