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Title: | Liquid Biopsies in the Clinical Management of Germ Cell Tumor Patients: State-of-the-Art and Future Directions | Authors: | Lobo, João Leão, Ricardo Jerónimo, Carmen Henriques, Rui T. |
Keywords: | germ cell tumors; liquid biopsies; microRNAs; DNA methylation; circulating tumor cells; biomarkers; diagnosis; follow-up; serum tumor markers | Issue Date: | 6-Mar-2021 | Publisher: | MDPI AG | Project: | project EpiMarkGermCell (PTDC/MEC-URO/29043/2017 FCT - SFRH/BD/132751/2017 MSD (“Prémio de Investigação em Saúde”), Banco Carregosa/ Secção Regional do Norte da Ordem dos Médicos (SRNOM) and Fundação Rui Osório de Castro/Millennium bcp. |
metadata.degois.publication.title: | International Journal of Molecular Sciences | metadata.degois.publication.volume: | 22 | metadata.degois.publication.issue: | 5 | Abstract: | Liquid biopsies constitute a minimally invasive means of managing cancer patients, entailing early diagnosis, follow-up and prediction of response to therapy. Their use in the germ cell tumor field is invaluable since diagnostic tissue biopsies (which are invasive) are often not performed, and therefore only a presumptive diagnosis can be made, confirmed upon examination of the surgical specimen. Herein, we provide an overall review of the current liquid biopsy-based biomarkers of this disease, including the classical, routinely used serum tumor markers-the promising microRNAs rapidly approaching the introduction into clinical practice-but also cell-free DNA markers (including DNA methylation) and circulating tumor cells. Finally, and importantly, we also explore novel strategies and challenges for liquid biopsy markers and methodologies, providing a critical view of the future directions for liquid biopsy tests in this field, highlighting gaps and unanswered questions. | URI: | https://hdl.handle.net/10316/104755 | ISSN: | 1422-0067 | DOI: | 10.3390/ijms22052654 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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