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Title: | Single Low Dose of Cocaine-Structural Brain Injury Without Metabolic and Behavioral Changes | Authors: | Nicolucci, Camilla Pais, Mariana Lapo Santos, A. C. Ribeiro, Fabiana M. Encarnação, Pedro M. C. C. Silva, Ana L. M. Castro, I. F. Correia, Pedro M. M. Veloso, João F. C. A. Reis, Julie Lopes, Marina Z. Botelho, Maria F. Pereira, Frederico C. Priolli, Denise G. |
Keywords: | cocaine; brain damage; metabolic imaging; histological change; behavior | Issue Date: | 2020 | Publisher: | Frontiers Media S.A. | Project: | FAPESP (São Paulo Research Foundation) 2015/07981-2 and 2017/26010-3; (B) the CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível 327 Superior – Brasil) 88887.176059/2018-00 project iPET CENTRO-01-0247-FEDER-039880, co-financed by the EU through FEDER project i3N, UIDB/50025/2020 and UIDP/50025/2020, financed by national funds through the FCT/MEC FCT - SFRH/BD/137800/2018 FCT - SFRH/BD/143964/2019 |
Serial title, monograph or event: | Frontiers in Neuroscience | Volume: | 14 | Abstract: | Chronic cocaine use has been shown to lead to neurotoxicity in rodents and humans, being associated with high morbidity and mortality rates. However, recreational use, which may lead to addictive behavior, is often neglected. This occurs, in part, due to the belief that exposure to low doses of cocaine comes with no brain damage risk. Cocaine addicts have shown glucose metabolism changes related to dopamine brain activity and reduced volume of striatal gray matter. This work aims to evaluate the morphological brain changes underlying metabolic and locomotor behavioral outcome, in response to a single low dose of cocaine in a pre-clinical study. In this context, a Balb-c mouse model has been chosen, and animals were injected with a single dose of cocaine (0.5 mg/kg). Control animals were injected with saline. A behavioral test, positron emission tomography (PET) imaging, and anatomopathological studies were conducted with this low dose of cocaine, to study functional, metabolic, and morphological brain changes, respectively. Animals exposed to this cocaine dose showed similar open field activity and brain metabolic activity as compared with controls. However, histological analysis showed alterations in the prefrontal cortex and hippocampus of mice exposed to cocaine. For the first time, it has been demonstrated that a single low dose of cocaine, which can cause no locomotor behavioral and brain metabolic changes, can induce structural damage. These brain changes must always be considered regardless of the dosage used. It is essential to alert the population even against the consumption of low doses of cocaine. | URI: | https://hdl.handle.net/10316/104549 | ISSN: | 1662-4548 | DOI: | 10.3389/fnins.2020.589897 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais |
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