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Title: Effect of Headgroup on DNA−Cationic Surfactant Interactions
Authors: Dasgupta, Antara 
Das, Prasanta Kumar 
Dias, Rita S. 
Miguel, Maria G. 
Lindman, Björn 
Jadhav, Vaibhav M. 
Gnanamani, Muthaiah 
Maiti, Souvik 
Issue Date: 26-Jul-2007
Publisher: American Chemical Society
Citation: The Journal of Physical Chemistry B. 111:29 (2007) 8502-8508
Abstract: The interaction behavior of DNA with different types of hydroxylated cationic surfactants has been studied. Attention was directed to how the introduction of hydroxyl substituents at the headgroup of the cationic surfactants affects the compaction of DNA. The DNA−cationic surfactant interaction was investigated at different charge ratios by several methods like UV melting, ethidium bromide exclusion, and gel electrophoresis. Studies show that there is a discrete transition in the DNA chain from extended coils (free chain) to a compact form and that this transition does not depend substantially on the architecture of the headgroup. However, the accessibility of DNA to ethidium bromide is preserved to a significantly larger extent for the more hydrophilic surfactants. This was discussed in terms of surfactant packing. Observations are interpreted to reflect that the surfactants with more substituents have a larger headgroup and therefore form smaller micellar aggregates; these higher curvature aggregates lead to a less efficient, “patch-like” coverage of DNA. The more hydrophilic surfactants also presented a significantly lower cytotoxicity, which is important for biotechnological applications.
ISSN: 1520-6106
DOI: 10.1021/jp068571m
Rights: openAccess
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais

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