Please use this identifier to cite or link to this item:
Title: Bioactive Antimicrobial Peptides as Therapeutic Agents for Infected Diabetic Foot Ulcers
Authors: Da Silva, Jessica
Leal, Ermelindo C. 
Carvalho, Eugenia 
Keywords: antimicrobial peptides; chronic non-healing wounds; diabetic foot ulcers; wound healing; bacterial and fungal infections; biofilms
Issue Date: 17-Dec-2021
Publisher: MDPI
Project: CENTRO-01-0145-FEDER-000012 
DL57/2016/CP1448/CT0024 (E.C.L.) 
PhD Scholarship 2020.04990.BD (J.D.S.) 
Serial title, monograph or event: Biomolecules
Volume: 11
Issue: 12
Abstract: Diabetic foot ulcer (DFU) is a devastating complication, affecting around 15% of diabetic patients and representing a leading cause of non-traumatic amputations. Notably, the risk of mixed bacterial-fungal infection is elevated and highly associated with wound necrosis and poor clinical outcomes. However, it is often underestimated in the literature. Therefore, polymicrobial infection control must be considered for effective management of DFU. It is noteworthy that antimicrobial resistance is constantly rising overtime, therefore increasing the need for new alternatives to antibiotics and antifungals. Antimicrobial peptides (AMPs) are endogenous peptides that are naturally abundant in several organisms, such as bacteria, amphibians and mammals, particularly in the skin. These molecules have shown broad-spectrum antimicrobial activity and some of them even have wound-healing activity, establishing themselves as ideal candidates for treating multi-kingdom infected wounds. Furthermore, the role of AMPs with antifungal activity in wound management is poorly described and deserves further investigation in association with antibacterial agents, such as antibiotics and AMPs with antibacterial activity, or alternatively the application of broad-spectrum antimicrobial agents that target both aerobic and anaerobic bacteria, as well as fungi. Accordingly, the aim of this review is to unravel the molecular mechanisms by which AMPs achieve their dual antimicrobial and wound-healing properties, and to discuss how these are currently being applied as promising therapies against polymicrobial-infected chronic wounds such as DFUs.
ISSN: 2218-273X
DOI: 10.3390/biom11121894
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
IIIUC - Artigos em Revistas Internacionais

Show full item record


checked on May 2, 2023

Page view(s)

checked on Apr 9, 2024


checked on Apr 9, 2024

Google ScholarTM




This item is licensed under a Creative Commons License Creative Commons